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Synthesis and Antimicrobial Activity of New Ureas from (1S,2S)-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol

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A series of new urea derivatives were synthesized from (1S,2S)-2-amino-1-(4-nitrophenyl)-1,3-propanediol and their antimicrobial activities were studied. Of the eight ureas synthesized here, only one compound had weak antimicrobial activity in relation to B. cereus and Candida spp.

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References

  1. I. Vatsouro, V. Rudzevich and V. Bohmer, Org. Let., 9(7), 1375 – 1377 (2007).

    Article  CAS  Google Scholar 

  2. E. Quinlan, S. E. Matthews and T. Gunnlaugsson, J. Org. Chem., 72(20), 7497 – 7503 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. S. Kh. Sharipova and V. P. Zaitsev, Khim.-Farm. Zh., 20(7), 858 – 862 (1986); Pharm. Chem. J., 20(7), (1986).

  4. V. P. Zaitsev, S. Kh. Sharipova, and I. I. Zhuravleva, Khim.- Farm. Zh., 32(3), 44 – 46 (1998); Pharm. Chem. J., 32(3), (1998).

  5. M. Madesclaire, S. Kh. Sharipova, A. V. Lyamin, et al., Khim.- Farm. Zh., 45(11), 20 – 22 (2011); Pharm. Chem. J., 45(11), (2011).

  6. Handbook for Preclinical Studies of Drugs [in Russian], A. N. Mironov (ed.), Grif i K, Moscow (2012).

  7. Methodological Guidelines MUK 4.2.1890 – 04. Determination of Microbial Sensitivity to Antibacterial Agents [in Russian].

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The authors would like to thank Fernand Leal, France, for assistance with these studies and constructive discussion of the results.

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Correspondence to V. P. Zaitsev.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 1, pp. 12 – 14, January, 2015.

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Madesclaire, M., Coudert, P., Lyamin, A.V. et al. Synthesis and Antimicrobial Activity of New Ureas from (1S,2S)-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol. Pharm Chem J 49, 10–12 (2015). https://doi.org/10.1007/s11094-015-1213-0

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  • DOI: https://doi.org/10.1007/s11094-015-1213-0

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