Poly(t-butylmethacrylate) with the optimal molecular-weight characteristics (M n = 12,400; MW/M n = 1.35) for biocompatible polymers was synthesized by radical polymerization in the presence of thioglycolic acid as a chain transfer agent. The obtained polymer was converted by acid hydrolysis into a water-soluble copolymer of t-butylmethacrylate and methacrylic acid of 20:80 mass%, respectively. The copolymer of t-butylmethacrylate and methacrylic acid was modified with folic acid, which has affinity for tumor cells. A conjugate of the copolymer with doxorubicin and also a conjugate containing folate vector were synthesized. Their formation was proved using IR and UV spectroscopy.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 12, pp. 46 – 50, December, 2014.
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Zhukova, O.V., Bulgakova, S.A. Synthesis of a Polymeric Doxorubicin Derivative and its Evaluation Using IR and UV Spectroscopy. Pharm Chem J 48, 830–834 (2015). https://doi.org/10.1007/s11094-015-1204-1
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DOI: https://doi.org/10.1007/s11094-015-1204-1