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Sterilizing Filtration for Production of Strontium-82 Active Pharmaceutical Ingredient

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Pharmaceutical Chemistry Journal Aims and scope

Sterilizing filtration for the production of strontium-82 obtained after radiochemical processing of irradiated rubidium-metal targets was developed. Pharmacopoeial microbiology sterility tests established that the process produced sterile Sr-82 active pharmaceutical ingredient and could be recommended for producing 82Sr/82Rb generators.

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References

  1. L. F. Mausner, Energy Facilities Contractors Group (EFCOG) Meeting, Brookhaven National Laboratory, Oct. 7, 2010 (2010).

  2. Strontium-82 Radiochemical Strontium Chloride Solution, Nordion, Sr-82 Fact Sheet (2013).

  3. B. L. Zhujkov, V. M. Kokhanjuk, and D. Vinsent, RU Pat. No. 2,102,808, Jan. 20, 1998 [see also B. L. Zhuikov, V. M. Kokhanjuk, and J. Vincent, US Pat. No. 5, 875, 220, Feb. 23, 1999].

  4. Rubidium Chloride Rb 82 Injection, U. S. Pharmacopoeia, 29, 1936 (2009).

  5. OFS 42-0066-07 Sterility, Russian Federation State Pharmacopoeia [in Russian], XIIth Ed., Part 1, Moscow (2007), p. 150.

  6. OFS 42-0073-07 Radiopharmaceuticals, Russian Federation State Pharmacopoeia [in Russian], XIIth Ed., Part 1, (2007), p. 456.

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Acknowledgments

The work was sponsored by the Ministry of Education and Science of the Russian Federation on the topic “Development of manufacturing technology for strontium-82, raw material for producing radiopharmaceuticals” under State Contract No. 16.522.12.2012.

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Authors and Affiliations

  1. A. I. Leipunsky Institute of Physics and Power Engineering, State Scientific Center of the Russian Federation, 1 Bondarenko Pl., Obninsk, Kaluga Oblast, 249033, Russia

    D. V. Stepchenkov, A. A. Semenova, E. G. Kuz’mina, S. V. Kham’yanov & N. A. Nerozin

  2. Medical Radiology Scientific Center, Ministry of Public Health and Social Development of the Russian Federation, 4 Koroleva Ul., Obninsk, Kaluga Oblast, 249036, Russia

    A. A. Kuznetsov & N. M. Rogova

Authors
  1. D. V. Stepchenkov
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  2. A. A. Semenova
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  3. E. G. Kuz’mina
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  4. A. A. Kuznetsov
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  5. N. M. Rogova
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  6. S. V. Kham’yanov
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  7. N. A. Nerozin
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 12, pp. 35 – 37, December, 2014.

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Stepchenkov, D.V., Semenova, A.A., Kuz’mina, E.G. et al. Sterilizing Filtration for Production of Strontium-82 Active Pharmaceutical Ingredient. Pharm Chem J 48, 819–821 (2015). https://doi.org/10.1007/s11094-015-1202-3

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  • DOI: https://doi.org/10.1007/s11094-015-1202-3

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