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Synthesis, Properties, and Biological Activity of N-Acyl(Alkenyl)-5-Iodo(H)Anthranilic Acid Amides

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Pharmaceutical Chemistry Journal Aims and scope

N-Substituted 5-iodo(H)anthranilic acid amides were synthesized by acylation of 5-iodoanthranilic acid amide in benzene with heating and by alkylation of anthranilic acid amide at room temperature. The synthesized compounds were studied for analgesic and anti-inflammatory activity and acute toxicity as compared with diclofenac sodium and sodium mefenamate. The search for new biologically active compounds among N-substituted 5-iodo(H)anthranilic acid amides was shown to be promising.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, Perm, 614990, Russia

    E. R. Kurbatov, L. M. Korkodinova, A. G. Gol’dshtein, T. I. Yarygina & A. S. Botalova

  2. Perm State National Research University, Perm, 614990, Russia

    L. G. Mardanova

Authors
  1. E. R. Kurbatov
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  2. L. M. Korkodinova
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  3. A. G. Gol’dshtein
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  4. T. I. Yarygina
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  5. L. G. Mardanova
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  6. A. S. Botalova
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 12, pp. 23 – 26, December, 2014.

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Kurbatov, E.R., Korkodinova, L.M., Gol’dshtein, A.G. et al. Synthesis, Properties, and Biological Activity of N-Acyl(Alkenyl)-5-Iodo(H)Anthranilic Acid Amides. Pharm Chem J 48, 791–794 (2015). https://doi.org/10.1007/s11094-015-1197-9

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  • DOI: https://doi.org/10.1007/s11094-015-1197-9

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