New derivatives of sterically hindered phenols were obtained. Their DNA-protective activity under UV irradiation was studied. The experimental results showed that the investigated compounds protected genetic material from both direct UVB radiation and reactive oxygen species generated in the cell by it. The new compounds were promising components for preparations that protect DNA from UV-radiation-induced damage.
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References
H. Soehnge, A. Ouhtit, and H. N. Ananthaswamy, Front. Biosci., 2, 538 – 551 (1997).
B. K. Armstrong and A. Kricker, J. Photochem. Photobiol., B, 63, 8 – 18 (2001).
I. Fridovich, Ann. N. Y. Acad. Sci., 893, 1 – 18 (1999).
Y. Jiang, C. Ke, A. Piotr, et al., Biophys. J., 93, 1758 – 1767 (2007).
E. A. Chugunova, M. A. Sazykina, E. M. Gibadullinaet, et al., Lett. Drug Des. Discovery, 10(2), 145 – 154 (2013).
R. G. Tagasheva, S. V. Bukharov, R. E. Timasheva, et al., Vestn. KGTU, No. 16, 48 – 51 (2011).
G. B. Zavilgelsky, V. Yu. Kotova, and I. V. Manukhov, Mutat. Res., 634, 172 – 176 (2007).
A. C. Vollmer, S. Belkin, D. R. Smulski, et al., Appl. Environ. Microbiol., 63, 2566 – 2571 (1997).
T. Maniatis, E. F. Fritsch, and J. Sambrook, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, New York (1982).
G. F. Lakin, Biometry [in Russian], Vysshaya Shkola, Moscow (1990).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 12, pp. 19 – 22, December, 2014.
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Oludina, Y.N., Sazykina, M.A., Prazdnova, E.V. et al. Synthesis of Modified Sterically Hindered Phenols and Investigation of Their Ability to Protect Bacterial DNA Against UVB Damage. Pharm Chem J 48, 787–790 (2015). https://doi.org/10.1007/s11094-015-1196-x
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DOI: https://doi.org/10.1007/s11094-015-1196-x