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Search for Chemical Compounds for Pharmacotherapy of Neurofibromatosis Type 2

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Pharmaceutical Chemistry Journal Aims and scope

A murine embryonic fibroblast cell line (MEF NF2-/-) was generated to model neurofibromatosis type 2 (NF2), a serious inherited disease for which there is no pharmacotherapeutic cure. Screening of a library of low-molecular-weight bioactive compounds using the experimental cell line MEF NF2-/- and MEF NF2f/f as a control cell line identified two agents, lovastatin and cerulenin, as potential candidates for NF2 pharmacotherapy.

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Authors and Affiliations

  1. Pirogov State Medical University, Moscow, 117997, Russia

    D. S. Stepanova & N. L. Shimanovskiy

  2. Fox Chase Cancer Center, Philadelphia, PA, 19111, United States

    D. S. Stepanova & J. Chernoff

Authors
  1. D. S. Stepanova
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  2. J. Chernoff
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  3. N. L. Shimanovskiy
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Corresponding author

Correspondence to D. S. Stepanova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 12, pp. 9 – 14, December, 2014.

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Stepanova, D.S., Chernoff, J. & Shimanovskiy, N.L. Search for Chemical Compounds for Pharmacotherapy of Neurofibromatosis Type 2. Pharm Chem J 48, 777–782 (2015). https://doi.org/10.1007/s11094-015-1194-z

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  • DOI: https://doi.org/10.1007/s11094-015-1194-z

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