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Synthesis and Antimicrobial and Antifungal Activities of 3-Substituted 1-Cyanomethyl-3,4-Dihydroisoquinolinium Chlorides

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3-Substituted [3,4-dihydroisoquinolin-1(2H)-ylidene]acetonitriles were synthesized via replacement of Cl by a cyano group in the corresponding 1-chloromethylisoquinolines. The hydrochlorides of the synthesized compounds exhibited weak antimicrobial and antifungal activities. The maximum activity against Staphylococcus aureus, Escherichia coli, and Candida albicans was observed for the compound with a 3-spiro-cyclopentyl radical, the MIC of which was 250 μg/mL.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 11, pp. 15 – 17, November, 2014.

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Surikova, O.V., Mikhailovskii, A.G. & Odegova, T.F. Synthesis and Antimicrobial and Antifungal Activities of 3-Substituted 1-Cyanomethyl-3,4-Dihydroisoquinolinium Chlorides. Pharm Chem J 48, 711–713 (2015). https://doi.org/10.1007/s11094-015-1178-z

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  • DOI: https://doi.org/10.1007/s11094-015-1178-z

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