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Comparative IR Spectroscopic Study of the Effects of Unithiol and its Disulfide Derivatives on the Reaction Between Acetaldehyde and Dopamine

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Pharmaceutical Chemistry Journal Aims and scope

IR spectroscopy showed that unithiol disulfide derivatives accelerated the reaction between acetaldehyde and dopamine, the product of which was a tetrahydroisoquinoline. Conversely, unithiol itself inhibited this reaction. This led to the conclusion that unithiol injection was inappropriate for prevention and treatment of alcoholism because injected unithiol was rapidly converted into its disulfide derivatives.

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Authors and Affiliations

  1. A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 29 Leninskii Prosp., Moscow, 119071, Russia

    G. N. Bondarenko

  2. National Scientific Narcology Center, 3 Malyi Mogil’tsevskii Per., Moscow, 119002, Russia

    S. M. Zenovich

Authors
  1. G. N. Bondarenko
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  2. S. M. Zenovich
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Correspondence to S. M. Zenovich.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 11, pp. 7 – 9, November, 2014.

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Bondarenko, G.N., Zenovich, S.M. Comparative IR Spectroscopic Study of the Effects of Unithiol and its Disulfide Derivatives on the Reaction Between Acetaldehyde and Dopamine. Pharm Chem J 48, 703–705 (2015). https://doi.org/10.1007/s11094-015-1176-1

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  • DOI: https://doi.org/10.1007/s11094-015-1176-1

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