We report here a comparative study of the effects of Russian-produced derivatives of 3-hydroxypyridine and succinic acid (emoxypine, Reamberin, and Mexidol) on the resistance of mice to acute adrenaline intoxication and formalin edema. The corresponding effects of α-lipoic acid (α-LA) were also studied - this has previously been used as a reference agent in assessments of the antihypoxic activity of 3-hydroxypyridine and succinic acid derivatives. Single doses of emoxypine, Reamberin, Mexidol, and α-LA at the optimum doses, corresponding to the therapeutic range for humans, were found to increase the duration of life in mice dying from acute adrenaline intoxication. α-LA was found to decrease formalin edema, while emoxypine and Mexidol increased its severity. The protective effects of all compounds tested against adrenalin intoxication were found to increase in direct proportion to their ability to increase formalin edema.
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References
I. A. Volchegorskii, M. G. Moskvicheva, and E. N. Chashchina, Ter. Arkhiv, 77(10), 10 – 15 (2005).
I. A. Volchegorskii, P. N. Novoselov, and T. V. Astakhova, Ter. Arkhiv, 81(11), 21 – 24 (2009).
I. A. Volchegorskii and K. M. Mester, Zh. Nevrol. Psikhiat. im. S. S. Korsakova, No. 3, 19 – 24 (2010).
I. A. Volchegorskii, E. V. Tur, O. V. Solyannikova, et al., Éksperim. Klin. Farmakol., 75(7), 20 – 26 (2012).
O. V. Kashichkina and N. A. Kriger, Byull. Éksperim. Biol. Med., Supplement 1, 167 – 171 (2006).
L. N. Semchenko, T. V. Drozdova, and M. N. Zinov’eva, Byull. Éksperim. Biol. Med., Supplement 1, 75 – 77 (2006).
I. A. Volchegorskii, I. I. Dolgushin, O. L. Kolesnikov, and V. É. Tseilikman, Experimental Modeling and Laboratory Assessment of the Adaptive Reactions of the Body [in Russian], Chelyabinsk State Pedagogical University Press, Chelyabinsk (2000).
I. A. Volchegorskii, L. M. Rassokhina, I. Yu. Miroshnichenko, Éksperim. Klin. Farmakol., 74(12), 27 – 32 (2011).
R. A. Kopaladze, Usp. Fiziol. Nauk., 29(4), 74 – 92 (1998).
V. V. Gatsura, Methods for Primary Pharmacological Studies of Biologically Active Compounds [in Russian], Meditsina, Moscow (1974).
L. A. Baltina, V. A. Davydova, I. G. Chikaeva, et al., Khim.-Farm. Zh., 22(6), 694 – 697 (1988); Chem. Pharm. J., 22(6), 460 – 462 (1988).
M. V. Bilenko, Ischemic and Reperfusion Damage to the Organs (Molecular Mechanisms, Approaches to Prevention, and Treatment) [in Russian], Meditsina, Moscow (1989).
I. Yu. Iskusnykh, T. N. Popova, and O. S. Musharova, Biomed. Khim., 58(5), 530 – 538 (2012).
O. A. Kislyak, T. O. Myshlyaeva, and N. V. Malysheva, Sakharn. Diabet., No. 1, 45 – 49 (2008).
I. A. Volchegorskii, L. M. Rassokhina, and I. Yu. Miroshnichenko, Byull. Éksperim. Biol. Med., 9, 295 – 301 (2010).
E. B. Men’shchikova, V. Z. Lankin, N. K. Zenkov, et al., Oxidative Stress. Prooxidants and Antioxidants [in Russian], Slovo, Moscow (2006).
I. V. Okunevich and N. S. Sapronov, Obzory Klin. Farmakol. Lekarstv. Ter., 3(3), 2 – 17 (2004).
A. V. Gnezdilova T. S. Gan’shina, and R. S. Mirzoyan, Éksperim. Klin. Farmakol., 73(10), 11 – 13 (2010).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 9, pp. 3 – 6, September, 2014.
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Volchegorskii, I.A., Miroshnichenko, I.Y. & Rassokhina, L.M. Effects of 3-hydroxypyridine and Succinic Acid Derivatives on Resistance to Acute Adrenaline Intoxication and Formalin Edema in Mice. Pharm Chem J 48, 565–568 (2014). https://doi.org/10.1007/s11094-014-1152-1
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DOI: https://doi.org/10.1007/s11094-014-1152-1