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Analytical Method Development for Tablets of the New Kappa-Opioid Agonist RU-1205

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An analytical method for tablets of the new imidazobenzimidazole kappa-opioid agonist RU-1205 was developed. The principal pharmacopoeial parameters of tablet quality were studied. The contents of impurities and RU-1205 in the tablets were assayed quantitatively using HPLC. A method for determining the dose uniformity using UV spectrophotometry was developed. Procedures were proposed for determining the authenticity and dissolution profile of RU-1205 tablets.

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References

  1. A. A. Spasov, V. A. Anisimova, P. M. Vasil’ev, et al., “Kappa-opioid agonist,” RU Pat. 2,413,512, Mar. 10, 2011; Byull. Izobret., No. 7 (2011).

  2. A. A. Illarionov, L. N. Grushevskaya, and L. M. Gaevaya, Khim.-farm. Zh., 48(5), 50 – 56 (2014).

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  3. USSR State Pharmacopoeia. XIth Ed., Meditsina, Moscow, 1990, p. 154.

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Authors and Affiliations

  1. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, 125315, Russia

    A. A. Illarionov, L. N. Grushevskaya, L. M. Gaevaya, M. E. Dudenkova, N. I. Avdyunina, B. M. Pyatin, K. V. Alekseev, E. V. Blynskaya & I. V. Bogunova

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  1. A. A. Illarionov
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  2. L. N. Grushevskaya
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  3. L. M. Gaevaya
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  4. M. E. Dudenkova
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  5. N. I. Avdyunina
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  6. B. M. Pyatin
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  7. K. V. Alekseev
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  8. E. V. Blynskaya
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  9. I. V. Bogunova
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 6, pp. 48 – 53, June, 2014.

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Illarionov, A.A., Grushevskaya, L.N., Gaevaya, L.M. et al. Analytical Method Development for Tablets of the New Kappa-Opioid Agonist RU-1205. Pharm Chem J 48, 408–413 (2014). https://doi.org/10.1007/s11094-014-1121-8

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  • DOI: https://doi.org/10.1007/s11094-014-1121-8

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