Skip to main content
SpringerLink
Log in

Improved Method for Isolating Temozolomide from its Dimethylsulfoxide Solvate

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

A simple method for isolating temozolomide, which is used to treat several types of malignant tumors, from its dimethylsulfoxide (DMSO) solvate was investigated. The method consisted of treating temozolomide DMSO solvate with a refluxing Me2CO:H2 O mixture. It was found that decreasing the H2O content in the mixture and reducing the reflux time improved the purity of the final product. The best result was obtained by refluxing the sample in anhydrous Me2CO. The reproducibility of the proposed method was demonstrated. It was established that the size of temozolomide crystals obtained by this method was much smaller than after recrystallization from aqueous Me2CO.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. J. N. Parker and P. M. Parker (eds.), Temozolomide: A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References, ICON Group International Inc., 2003.

  2. M. F. G. Stevens, J. A. Hickman, S. P. Langdon, et al., Cancer Res., 47, 5846 – 5852 (1987).

    PubMed  CAS  Google Scholar 

  3. B. J. Denny, R. T. Wheelhouse, M. F. G. Stevens, et al., Biochemistry, 33, 9045 – 9051 (1994).

    Article  PubMed  CAS  Google Scholar 

  4. A. S. Clark, B. Deans, M. F. G. Stevens, et al., J. Med. Chem., 38, 1493 – 1504 (1995).

    Article  PubMed  CAS  Google Scholar 

  5. R. T. Wheelhouse, D. E. V. Wilman, W. Thomson, and M. F. G. Stevens, J. Chem. Soc. Perkin Trans. 1, 249 – 252 (1995).

  6. R. V. Palle, A. M. Marathe, and A. Manda, US Pat. Appl. No. 20070225496, Sep. 27, 2007; Chem. Abstr., 147, 406849 (2007).

    Google Scholar 

  7. G. Ege, K. Gilber, and K. Maurer, Chem. Ber., 120(8), 1375 – 1395 (1987).

    Article  CAS  Google Scholar 

  8. Rep. Belarus Pat. 16085; http: // www.belgospatent.org.by/database/search.php?pref=inv&page=3&target=MjAxMDEzNjE.

  9. M. F. G. Stevens, J. A. Hickman, R. Stone, et al., J. Med. Chem., 27(2), 196 – 201 (1984).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Belarusian State University, Minsk, Belarus

    Yu. Yu. Kozyr’kov & E. A. Matyushenkov

  2. National Anti-Doping Laboratory, Lesnoi, Belarus

    S. A. Belyaev

Authors
  1. Yu. Yu. Kozyr’kov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. A. Matyushenkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. A. Belyaev
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 6, pp. 44 – 47, June, 2014.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kozyr’kov, Y.Y., Matyushenkov, E.A. & Belyaev, S.A. Improved Method for Isolating Temozolomide from its Dimethylsulfoxide Solvate. Pharm Chem J 48, 398–401 (2014). https://doi.org/10.1007/s11094-014-1119-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-014-1119-2

Keywords

Search

Navigation