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Biochemical and Morphological Changes in White Rats After Intragastric Injecton of a Synthetic Nanobiocomposite Based on Silver Nanoparticles and Arabinogalactan

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Pharmaceutical Chemistry Journal Aims and scope

Results from the synthesis and biological testing of a new nanobiocomposite containing silver (Ag) nanoparticles encapsulated in the natural biologically active polymer arabinogalactan were presented. The physicochemical properties of the water-soluble Ag-containing polymeric nanocomposite were described. It was found that the new nanocomposite upon intragastric injection to white rats activated the antioxidant system, caused slight changes in brain and liver tissues, and produced biochemical shifts characteristic of compensatory—adaptive stress mechanisms.

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Authors and Affiliations

  1. Research Institute of Occupational Medicine and Human Ecology, Siberian Branch, Russian Academy of Medical Sciences, P. O. Box 1170, Angarsk, 665827, Russia

    M. A. Novikov, E. A. Titov & L. M. Sosedova

  2. Favorsky Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Ul. Favorskogo, Irkutsk, 664033, Russia

    L. A. Ostroukhova, N. N. Trofimova & V. A. Babkin

Authors
  1. M. A. Novikov
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  2. E. A. Titov
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  3. L. M. Sosedova
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  4. L. A. Ostroukhova
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  5. N. N. Trofimova
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  6. V. A. Babkin
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 6, pp. 33 – 36, June, 2014.

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Novikov, M.A., Titov, E.A., Sosedova, L.M. et al. Biochemical and Morphological Changes in White Rats After Intragastric Injecton of a Synthetic Nanobiocomposite Based on Silver Nanoparticles and Arabinogalactan. Pharm Chem J 48, 387–390 (2014). https://doi.org/10.1007/s11094-014-1116-5

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  • DOI: https://doi.org/10.1007/s11094-014-1116-5

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