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Synthesis and Antioxidant Activity of 2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carbamides

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Pharmaceutical Chemistry Journal Aims and scope

A series of 2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbamides were synthesized by a three-component condensation of acetoacetamides, aromatic aldehydes, and thiourea. Their structures were confirmed by IR and PMR spectroscopy and mass spectrometry. Compounds exhibiting high inhibitory activity against superoxide generation by mitochondria in the liver and in transformed tissue of tumor-bearing rats were discovered.

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Authors and Affiliations

  1. Fedkovych Chernivtsy National University, 58002, Chernivtsy, Ukraine

    O. V. Kushnir, O. N. Voloshchuk, R. I. Eften’eva & M. M. Marchenko

  2. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 02660, Kiev, Ukraine

    M. V. Vovk

Authors
  1. O. V. Kushnir
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  2. O. N. Voloshchuk
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  3. R. I. Eften’eva
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  4. M. M. Marchenko
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  5. M. V. Vovk
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Corresponding author

Correspondence to O. V. Kushnir.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 4, pp. 25 – 27, April, 2014.

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Kushnir, O.V., Voloshchuk, O.N., Eften’eva, R.I. et al. Synthesis and Antioxidant Activity of 2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carbamides. Pharm Chem J 48, 246–248 (2014). https://doi.org/10.1007/s11094-014-1087-6

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  • DOI: https://doi.org/10.1007/s11094-014-1087-6

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