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Pharmaceutical Chemistry Journal

, Volume 48, Issue 4, pp 246–248 | Cite as

Synthesis and Antioxidant Activity of 2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carbamides

  • O. V. KushnirEmail author
  • O. N. Voloshchuk
  • R. I. Eften’eva
  • M. M. Marchenko
  • M. V. Vovk
Article

A series of 2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbamides were synthesized by a three-component condensation of acetoacetamides, aromatic aldehydes, and thiourea. Their structures were confirmed by IR and PMR spectroscopy and mass spectrometry. Compounds exhibiting high inhibitory activity against superoxide generation by mitochondria in the liver and in transformed tissue of tumor-bearing rats were discovered.

Keywords

2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbamides Biginelli reaction condensation superoxide anion-radical superoxide generation Heren’s carcinoma 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • O. V. Kushnir
    • 1
    Email author
  • O. N. Voloshchuk
    • 1
  • R. I. Eften’eva
    • 1
  • M. M. Marchenko
    • 1
  • M. V. Vovk
    • 2
  1. 1.Fedkovych Chernivtsy National UniversityChernivtsyUkraine
  2. 2.Institute of Organic ChemistryNational Academy of Sciences of UkraineKievUkraine

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