The antihypoxic activity of humic acids of Tomsk lowland peat was studied experimentally. It was established that native humic acids of peat (HAP) had pronounced antihypoxic activity after a preventive intragastric administration to mice, increasing the lifespan of animals and decreasing the lethality under hypobaric hypoxic and histotoxic hypoxia conditions. The discovered antihypoxic properties of HAP were probably due to their protective antioxidant properties, which prevent free-radical injury to cells and organelles under hypoxia conditions.
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V. E. Kagan, T. D. Churakova, and V. P. Karagodin, Byull. Eksp. Biol. Med., No. 2, 145 – 149 (1979).
K. G. Karagezyan, L. L. Danilova, G. O. Badalyan, et al., Kardiologiya, No. 2, 100 – 102 (1987).
Yu. P. Kozlov, V. E. Kagan, and Yu. V. Arkhipenko, Molecular Mechanisms of Oxygen Damage of Calcium Transport Systems in Sarcoplasmic Reticulum of Mice [in Russian], Izd. Irkutsk. Gos. Univ., Irkutsk (1983).
E. V. Roitman, I. I. Dement’eva, O. A. Azizova, et al., Tromboz, Gemostaz Reologiya, No. 1, 15 – 17 (2000).
Yu. O. Teselkin, B. A. Zhambalova, and I. V. Babenkova, Biofizika, No. 3, 620 – 623 (1996).
J. B. Furness, J. L. Bornstein, R. Murphy, et al., Trends Neurosci., 15(2), 66 – 71 (1992).
Yu. A. Vladimirov and E. M. Kogan, Kardiologiya, No. 1, 82 – 85 (1981).
Yu. Ya. Lazarevich and M. D. Maevskaya, Anasteziol. Reanimatol., No. 2, 3 – 11 (1980).
G. V. Naumova, V. P. Strigutskii, N. A. Zhmakova, et al., Khim. Tverd. Topl., No. 2, 3 – 13 (2001).
N. V. Yudina, S. I. Pisareva, and A. S. Saratikov, Khim. Tverd. Topl., No. 5, 31 – 34 (1996).
V. I. Saldan, in: Abstracts of the 12 th International Peat Congress, Tampere, Finland (2004), pp. 1205 – 1208.
V. P. Solovieva, H. P. Sotnikova, and T. D. Lotosh, in: Abstracts of the 10 th International Peat Congress, Germany (1996), pp. 137 – 140.
N. G. Vyazova, V. N. Kryukova, and V. P. Latyshev, Khim. Tverd. Topl., No. 6, 47 – 50 (1999).
N. I. Gamayunov, B. I. Maslennikov, and Yu. A. Shul’man, Pochvovedenie, No. 1, 113 – 116 (1992).
A. G. Zavarzina and V. V. Demin, Pochvovedenie, No. 10, 1246 – 1254 (1999).
A. I. Popov, Humic Substances: Properties, Structure, Formation [in Russian], Izd. St. Petersburg Univ. St. Petersburg (2004).
V. M. Bogolyubov and G. N. Ponomarenko, General Physiotherapy [in Russian], SLP, Moscow, St. Petersburg (1996), pp. 433 – 437.
E. S. Kashitskii, V. M. Kozin, V. S. Ulashchik, et al., Izv. Beloruss. Inzh. Akad., No. 2(8), 53 – 56 (1999).
V. M. Kozin, V. M. Semenov, and D. S. Yanushevskii, Vestn. Vitebsk. Gos. Med. Univ., 4(4), 93 – 96 (2005).
M. Kuhnert, V. Fuchs, and S. Golbs, in: Proceedings of the International Symposium, 4 and 2 Commissions MTO, Minsk (1982), pp. 232 – 243.
R. U. Khabriev, Handbook of Experimental (Preclinical) Study of New Drugs [in Russian], Meditsina, Moscow (2005).
R. U. Ostrovskaya, S. S. Trofimov, Yu. V. Burov, et al., Khim.- farm. Zh., 27(8), 13 – 16 (1993)
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 2, pp. 29 – 31, February, 2014.
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Belousov, M.V., Akhmedzhanov, R.R., Zykova, M.V. et al. Antihypoxic Activity of Native Humic Acids of Tomsk Lowland Peat. Pharm Chem J 48, 97–99 (2014). https://doi.org/10.1007/s11094-014-1056-0
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DOI: https://doi.org/10.1007/s11094-014-1056-0