It was established that an inorganic film of osmium(III) hexacyanocobaltate(II) (OHCC) deposited on the surface of a glassy carbon (GC) electrode exhibited catalytic activity for electro-oxidation of acetylcysteine (AC). The catalytic effect was manifested by a greater than 300 mV decrease in the oxidation potential and a many-fold increase in the current of substrate oxidation. The conditions for electrodeposition of the OHCC film on the GC electrode that gave the maximum catalytic effect for AC oxidation were determined. The parameters for the AC oxidation kinetics at this electrode were found. A voltammetric method for AC determination using the electrocatalytic response of the modified electrode was developed. The catalytic current was a linear function of analyte concentration in the range from 5 μM to 5 mM. The proposed method was used to determine AC in drugs.
Similar content being viewed by others
References
D. Harada, S. Naito, Y. Kawauchi, et al., Anal. Biochem., 290(2), 251 – 259 (2001).
B. Toussaint, C. Pitti, B. Streel, et al., J. Chromatogr. A, 896(1 – 2), 191 – 199 (2000).
P. Redondo, E. Bandres, T. Solano, et al., Cytokine, 12(4), 374 – 378 (2000).
A. A. Ensafi, H. Karimi-Maleh, S. Mallakpour, et al., Sens. Actuators, B, 155, 464 – 472 (2011).
V. Concha-Herrera, J. R. Torres-Lapasio, and M. C. Garcia-Alvarez-Coque, J. Liq. Chromatogr. Relat. Technol., 27(10), 1593 – 1609 (2004).
L. Chuan, L. Gangyi, J. Jindying, et al., Biomed. Chromatogr., 25(4), 427 – 431 (2011).
W. T. Suarez, O. D. Pessoa-Neto, B. C. Janegitz, et al., Anal. Lett., 44(14), 2394 – 2405 (2011).
W. T. Suarez, H. J. Vieira, O. Fatibello-Filho, et al., J. Pharm. Biomed. Anal., 37(4), 771 – 775 (2005).
W. T. Suarez, H. J. Vieira, and O. Fatibello-Filho, Acta Chim. Slov., 52, 164 – 167 (2005).
M. Kolar and D. Dobcnik, Pharmazie, 58(1), 25 – 28 (2003).
D. R. do Carmo, R. M. da Silva, and N. R. Stradiotto, J. Braz. Chem. Soc., 14(4), 616 – 620 (2003).
H. Karimi-Maleh, M. Keyvanfard, K. Alizad, et al., Int. J. Electrochem. Sci., 6, 6141 – 6150 (2011).
S. Al-Ghannam, A. El-Brashy, and B. Al-Farhan, Il Farmaco, 57(8), 625 – 629 (2002).
L. G. Shaidarova and G. K. Budnikov, Zh. Anal. Khim., 63(10), 1014 – 1037 (2008).
M. M. Kaplun, Yu. E. Smirnov, V. Mikli, et al., Elektrokhimiya, 37(9), 1065 – 1075 (2001).
V. D. Ivanov and A. R. Alieva, Elektrokhimiya, 38(8), 966 – 975 (2001).
L. G. Shaidarova, S. A. Zaripova, L. N. Tikhonova, et al., Zh. Prikl. Khim., 74(5), 728 – 732 (2001).
L. G. Sahidarova and G. K. Budnikov, in: Problems in Analytical Chemistry, Vol. 14, Chemical Sensors [in Russian], Yu. G. Vlasova (ed.), Nauka, Moscow (2011), pp. 203 – 284.
E. Laviron, J. Electroanal. Chem., 101(1), 19 – 28 (1979).
C. P. Andrieux and J. M. Saveant, J. Electroanal. Chem., 93(2), 163 – 168 (1978).
A. K. Charykov, Mathematical Processing of Analytical Chemical Results: Methods for Detecting and Estimating Errors [in Russian], Khimiya, Leningrad (1984), p. 168.
Acknowledgments
The work was supported financially by the Russian Foundation for Basic Research (Grant No. 12-03-97031-p povolzh’e a).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 12, pp. 48 – 52, December, 2013.
Rights and permissions
About this article
Cite this article
Shaidarova, L.G., Gedmina, A.V., Zhaldak, E.R. et al. Voltammetric Determination of Acetylcysteine in Drugs Using an Electrode Modified by an Osmium Hexacyanocobaltate Film. Pharm Chem J 47, 670–674 (2014). https://doi.org/10.1007/s11094-014-1029-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-014-1029-3