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Synthesis and Neurotropic Activity of 8-Amino Derivatives of Condensed Thieno[3,2-d]- and Furo[3,2-d]Pyrimidines

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Pharmaceutical Chemistry Journal Aims and scope

New derivatives of pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines based on 3-chloro derivatives of pyrano[3,4-c]pyridines and pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]furo[3,2-d]pyrimidines based on previously prepared 8-chloro derivatives were synthesized. Studies of the biological activity of the synthesized compounds showed that several of them exhibited neurotropic properties.

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Notes

  1. Resonances for the 2,2-dimethylpyran ring practically did not differ from those of VIa; therefore, they are not given further.

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Authors and Affiliations

  1. Mndjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, 375014, Armenia

    S. N. Sirakanyan, A. A. Ovakimyan, A. S. Noravyan, I. A. Dzhagatspanyan, I. M. Nazaryan & A. G. Akopyan

  2. Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, 375014, Armenia

    N. S. Minasyan

Authors
  1. S. N. Sirakanyan
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  2. A. A. Ovakimyan
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  3. A. S. Noravyan
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  4. N. S. Minasyan
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  5. I. A. Dzhagatspanyan
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  6. I. M. Nazaryan
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  7. A. G. Akopyan
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Corresponding author

Correspondence to S. N. Sirakanyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 12, pp. 33 – 37, December, 2013.

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Sirakanyan, S.N., Ovakimyan, A.A., Noravyan, A.S. et al. Synthesis and Neurotropic Activity of 8-Amino Derivatives of Condensed Thieno[3,2-d]- and Furo[3,2-d]Pyrimidines. Pharm Chem J 47, 655–659 (2014). https://doi.org/10.1007/s11094-014-1026-6

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  • DOI: https://doi.org/10.1007/s11094-014-1026-6

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