The Impact of Carotenoids on Immunity (Review)

The review covered carotenoids, a large class of natural compounds characterized by a broad spectrum of biological effects, one of which is the ability to influence the immune system. Their mechanisms of action on the human immune system were discussed. The ability of carotenoids to influence both humoral immunity and cellular immunity opens prospects for using these agents in the therapy of a wide range of diseases such as cancer, infectious diseases, neurodegenerative disorders, inflammatory processes, cardiovascular pathology, etc. The latest investigations of the role of carotenoids in gene regulation, apoptosis, and angiogenesis revealed some possible mechanisms of immune system regulation.

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References

  1. 1.

    A. Bendich, Proc. Nutr. Soc., 50, 263–274 (1991).

    CAS  PubMed  Article  Google Scholar 

  2. 2.

    C. Lingen, L. Ernster, and O. Lindberg, Exp. Cell Res., 16, 384–393 (1959).

    CAS  PubMed  Article  Google Scholar 

  3. 3.

    S. N. Meydani, D. Wu, and M. S. Santos, Am. J. Clin. Nutr., 62, 1462–1476 (1995).

    Google Scholar 

  4. 4.

    S. Gruner, H. D. Volk, and P. Falck, Eur. J. Immunol., 16, 212–215 (1986).

    CAS  PubMed  Article  Google Scholar 

  5. 5.

    N. Krinsky, Carotenoids in Health and Disease, Dekker, New York (2004), pp. 503–518.

    Google Scholar 

  6. 6.

    M. K. Shigenaga, T. M. Hagen, and B. N. Ames, Proc. Natl. Acad. Sci. USA, 91, 10771–10778 (1994).

    CAS  PubMed  Article  Google Scholar 

  7. 7.

    J. S. Park, B. P. Chew, and T. S. Wong, Nutr. Cancer, 33, 206–212 (1999).

    CAS  PubMed  Article  Google Scholar 

  8. 8.

    C. R. Baskin, K. W. Hinchcliff, and R. A. DiSilvestro, Am. J. Vet. Res., 61, 886–891 (2000).

    CAS  PubMed  Article  Google Scholar 

  9. 9.

    B. P. Chew, J. S. Park, and B. C. Weng, J. Nutr., 130, 1788–1791 (2000).

    CAS  PubMed  Google Scholar 

  10. 10.

    J. S. Park, H. W. Kim, and B. D. Mathison, Nutr. Metab., 7, 52–59 (2010).

    Article  Google Scholar 

  11. 11.

    M. M. Mathews-Roth, Clin. Chem., 24, 700–701 (1978).

    CAS  PubMed  Google Scholar 

  12. 12.

    B. P. Chew, T. S. Wong, and J. J. Michal, J. Anim. Sci., 71, 730–739 (1993).

    CAS  PubMed  Google Scholar 

  13. 13.

    B. P. Chew, T. S. Wong, J. J. Michal, et al., J. Anim. Sci., 69(12), 4892–4897 (1991).

    CAS  PubMed  Google Scholar 

  14. 14.

    B. P. Chew and J. S. Park, J. Nutr., 134, 257–261 (2004).

    Google Scholar 

  15. 15.

    A. L. Garcia, R. Rihl, and U. Herz, Immunology, 110, 180–187 (2003).

    CAS  PubMed  Article  Google Scholar 

  16. 16.

    N. Krinsky, Proc. Soc. Exp. Biol. Med., 218, 95–97 (1998).

    CAS  PubMed  Article  Google Scholar 

  17. 17.

    T. Kobayashi, K. Iijima, and T. Mitamura, Anti-cancer Drugs, 7, 195–198 (1996).

    CAS  PubMed  Article  Google Scholar 

  18. 18.

    D. A. Hughes, Nutrition, 17, 823–827 (2001).

    CAS  PubMed  Article  Google Scholar 

  19. 19.

    A. Bendich and S. S. Shapiro, J. Nutr., 116, 2254–2262 (1986).

    CAS  PubMed  Google Scholar 

  20. 20.

    M. B. Toomey, M. W. Butler, and K. J. McGraw, J. Exp. Biol., 213, 1709–1716 (2010).

    CAS  PubMed  Article  Google Scholar 

  21. 21.

    T. Sepp, U. Karu, and E. Sild, Exp. Parasitol., 127, No. 3, 651–657 (2011).

    CAS  PubMed  Article  Google Scholar 

  22. 22.

    P. S. Fitze, B. Tschirren, and J. Gasparini, Am. Nat., 169, 137–144 (2007).

    Article  Google Scholar 

  23. 23.

    C. D. Hoskinson, B. P. Chew, and T. S. Wong, Biol. Neonate, 62, 325–336 (1992).

    CAS  PubMed  Article  Google Scholar 

  24. 24.

    L. R. Daniel, B. P. Chew, and T. S. Tanaka, J. Dairy Sci., 74, 124–131 (1991).

    CAS  PubMed  Article  Google Scholar 

  25. 25.

    G. Van Poppel, S. Spanhaak, and T. Ockhuizen, Am. J. Clin. Nutr., 57, 402–407 (1993).

    PubMed  Google Scholar 

  26. 26.

    S. Moriguchi, N. Okishima, and S. Sumida, Nutr. Res., 16, 211–218 (1996).

    CAS  Article  Google Scholar 

  27. 27.

    T. R. Kramer and B. J. Burri, Am. J. Clin. Nutr. 65, 871–875 (1997).

    CAS  PubMed  Google Scholar 

  28. 28.

    B. P. Chew, J. S. Park, and M. W. Wong, Anticancer Res., 19, 1849–1853 (1999).

    CAS  PubMed  Google Scholar 

  29. 29.

    W. C. Van Hoorhis, J. Valinski, and E. Hoffman, J. Exp. Med., 158, 174–191 (1983).

    Article  Google Scholar 

  30. 30.

    G. Y. Kim, J. H. Kim, and S. C. Ahn, Immunology, 113, No. 2, 203–211 (2004).

    CAS  PubMed  Article  Google Scholar 

  31. 31.

    J. L. Schwartz, E. Flynn, and G. Shklar, Micronutr. Immunol. Function, 587, 92–109 (1990).

    CAS  Google Scholar 

  32. 32.

    J. J. Michal, B. P. Chew, and T. S. Wong, J. Diary Sci., 77, 1408–1422 (1994).

    CAS  Article  Google Scholar 

  33. 33.

    W. Zhao, Y. Han, and B. Zhao, Biochim. Biophys. Acta, General Subjects, 1381(1), 77–88 (1998).

    CAS  Article  Google Scholar 

  34. 34.

    B. P. Chew, J. S. Park, and T. S. Wong, J. Nutr., 130, 1910–1913 (2000).

    CAS  PubMed  Google Scholar 

  35. 35.

    H. W. Kim, B. P. Chew, and T. S. Wong, Vet. Immunol. Immunopath., 74, 315–327 (2000).

    CAS  Article  Google Scholar 

  36. 36.

    S. Massimino, R. J. Kearns, and K. M. Loos, J. Vet. Intern. Med., 17, 835–842 (2004).

    Article  Google Scholar 

  37. 37.

    H. W. Kim, B. P. Chew, and T. S. Wong, Vet. Immunol. Immunopath., 73, 331–341 (2000).

    CAS  Article  Google Scholar 

  38. 38.

    W. Fawzi, M. G. Herrera, and P. Nestel, J. Nutr., 130, 2537–2542 (2000).

    CAS  PubMed  Google Scholar 

  39. 39.

    A. Bub, B.Watzl, and L. Abrahamse, J. Nutr., 130, 2200–2206 (2000).

    CAS  PubMed  Google Scholar 

  40. 40.

    B. Watzl, A. Bub, and K. Briviba, Ann. Nutr. Metab., 47, 255–261 (2003).

    CAS  PubMed  Article  Google Scholar 

  41. 41.

    B.Watzl, A. Bub, and M. Blockhaus, J. Nutr., 130, 1719–1723 (2000).

    CAS  PubMed  Google Scholar 

  42. 42.

    M. S. Santos, L. S. Leka, and J. D. Ribaya-Mercado, Am. J. Clin. Nutr., 55, 917–924 (1997).

    Google Scholar 

  43. 43.

    M. S. Santos, S. N. Meydani, and L. S. Leka, Am. J. Clin. Nutr., 64, 772–777 (1996).

    CAS  PubMed  Google Scholar 

  44. 44.

    D. Albanes, Am. J. Clin. Nutr., 69, 1345–1350 (1999).

    Google Scholar 

  45. 45.

    C. N. Holick, D. S. Michaud, and R. Stolzenberg-Solomon, Am. J. Epidemiol., 156, 536–547 (2002).

    PubMed  Article  Google Scholar 

  46. 46.

    C. L. Rock, L. Natarajan, M. Pu, and C. A. Thomson, Cancer Epidemiol. Biomarkers Prev., 18, 486–494 (2009).

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  47. 47.

    D. S. Michaud, D. Feskanich, and E. B. Rimm, Am. J. Clin. Nutr., 72, 990–997 (2000).

    CAS  PubMed  Google Scholar 

  48. 48.

    B. L. Pool-Zobel, A. Bub, and H. Muller, Carcinogenesis, 18(9), 1847–1850 (1997).

    CAS  PubMed  Article  Google Scholar 

  49. 49.

    P. Riso, A. Pinder, and A. Santangelo, Am. J. Clin. Nutr., 69, 712–718 (1999).

    CAS  PubMed  Google Scholar 

  50. 50.

    J. S. Park, J. H. Chyun, and Y. K. Kim, Nutr. Metab., 7, No. 18, 1–10 (2010).

    Google Scholar 

  51. 51.

    S. Bhagavathya and P. Sumathib, Asian Pac. J. Trop. Biomed., 2, No. 2, 109–117 (2012).

    Article  Google Scholar 

  52. 52.

    C. R. Baskin, K. W. Hinchcliff, and R. A. DiSilvestro, Am. J. Vet. Res., 61, 886–891 (2000).

    CAS  PubMed  Article  Google Scholar 

  53. 53.

    L. A. Herraiz, W. C. Hsieh, and R. S. Parker, J. Am. Coll. Nutr., 17, 617–624 (1998).

    CAS  PubMed  Article  Google Scholar 

  54. 54.

    C. J. Fuller, H. Faulkner, and A. Bendich, Am. J. Clin. Nutr., 56, 684–690 (1992).

    CAS  PubMed  Google Scholar 

  55. 55.

    C. Lindholm, M. Quiding-Jarbink, and H. Lonroth, Infect. Immun., 66, 5964–5971 (1998).

    CAS  PubMed Central  PubMed  Google Scholar 

  56. 56.

    M. Bennedsen, X. Wang, and R. Willen, Immunol. Lett., 70, 185–189 (1999).

    CAS  PubMed  Article  Google Scholar 

  57. 57.

    H. Van Remmen and A. Richardson, Exp. Gerontol., 36, 957–968 (2001).

    CAS  PubMed  Article  Google Scholar 

  58. 58.

    S. Massimino, R. J. Kearns, and K. M. Loos, J. Vet. Intern. Med., 17, No. 6, 835–842 (2003).

    PubMed  Article  Google Scholar 

  59. 59.

    J. M. Van der Horst-Graat, F. J. Kok, and E. G. Schouten, Br. J. Nutr., 92, 113–118 (2004).

    PubMed  Article  Google Scholar 

  60. 60.

    M. F. Beal, Ann. Neurol., 58(4), 495–505 (2005).

    CAS  PubMed  Article  Google Scholar 

  61. 61.

    V. H. Perry, C. Cunningham, and D. Boche, Curr. Opin. Neurol., 15, 349–354 (2002).

    PubMed  Article  Google Scholar 

  62. 62.

    R. P. Copp, T. Wisniewski, and F. Hentati, Brain Res., 822, 80–87 (1999).

    CAS  PubMed  Article  Google Scholar 

  63. 63.

    J. J. Mitchell, M. Paiva, and M. B. Heaton, Neurosci. Lett., 263, 189–192 (1999).

    CAS  PubMed  Article  Google Scholar 

  64. 64.

    D. J. Pattison, D. P. M. Symmons, and M. Lunt, Am. J. Clin. Nutr., 82, 451–455 (2005).

    CAS  PubMed  Google Scholar 

  65. 65.

    J. R. Cerhan, K. J. Saag, L. A. Merlino, T. R. Mikuls, and L. A. Criswell, Am. J. Epidemiol., 157, 345–354 (2003).

    PubMed  Article  Google Scholar 

  66. 66.

    Y. Tomita, K. Himeno, and K. Nomoto, J. Natl. Cancer Inst., 78, 679–681 (1987).

    CAS  Google Scholar 

  67. 67.

    P. Prakash, R. M. Russell, and N. I. Krinsky, Nutrition, 131, 1574–1580 (2001).

    CAS  Google Scholar 

  68. 68.

    H. Jyonouchi, S. Sun, and K. Iijima, Nutr. Cancer, 36(1), 59–65 (2000).

    CAS  PubMed  Article  Google Scholar 

  69. 69.

    B. P. Chew, M. W. Wong, and T. S. Wong, Anticancer Res., 17, 3689–3694 (1996).

    Google Scholar 

  70. 70.

    J. S. Park, B. P. Chew, and T. S. Wong, J. Nutr., 128, 1650–1656 (1998).

    CAS  PubMed  Google Scholar 

  71. 71.

    J. Folkman, Perspect. Biol. Med., 29, 10–36 (1985).

    CAS  PubMed  Google Scholar 

  72. 72.

    B. P. Chew, C. M. Brown, and J. S. Park, Anticancer Res., 23, 3333–3339 (2003).

    CAS  PubMed  Google Scholar 

  73. 73.

    J. L. Schwartz and G. Shklar, Nutr. Cancer, 27(2), 192–199 (1997).

    CAS  PubMed  Article  Google Scholar 

  74. 74.

    C. J. Lacey, M. E. Murphy, and M. J. Sanderson, Int. J. STD AIDS, 7, 485–489 (1996).

    CAS  PubMed  Article  Google Scholar 

  75. 75.

    R. Ullrich, T. Schneider, and W. Heise, AIDS, 8 661–666 (1994).

    CAS  PubMed  Article  Google Scholar 

  76. 76.

    A. Metzger, G. Mukasa, and A. H. Shankar, Am. J. Trop. Med. Hyg., 65(2), 115–119 (2001).

    CAS  PubMed  Google Scholar 

  77. 77.

    G. O. Coodley, H. D. Nelson, and M. O. Loveless, J. Acquired Immune Defic. Syndr., 6, 272–276 (1993).

    CAS  Google Scholar 

  78. 78.

    A. Bianchi-Santamaria, S. Fedeli, and L. Santamaria, Med. Oncol. Med. Tumor Pharmacother., 9, 151–153 (1992).

    CAS  Google Scholar 

  79. 79.

    J. Austin, N. Sibghal, and R. Voigt, Eur. J. Clin. Nutr., 60, 1266–1276 (2006).

    CAS  PubMed  Article  Google Scholar 

  80. 80.

    G. E. Kaugars, S. Silverman, Jr., and G. L. Jonh, Oral Surg. Oral Med. Oral Pathol., 81, 5–14 (1996).

    CAS  Article  Google Scholar 

  81. 81.

    W. W. Fawzi, G. I. Msamanga, and D. Hunter, AIDS, 16, 1935–1944 (2002).

    CAS  PubMed  Article  Google Scholar 

  82. 82.

    E. Villamor and W. W. Fawzi, Clin. Microbiol. Rev., 18, 446–464 (2005).

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  83. 83.

    M. L. Watkins, J. D. Erickson, and M. J. Thun, Am. J. Epidemiol., 152, 149–162 (2000).

    CAS  PubMed  Article  Google Scholar 

  84. 84.

    C. H. Hennekens, J. E. Buring, and J. E. Manson, N. Engl. J. Med., 334(18), 1145–1149 (1996).

    CAS  PubMed  Article  Google Scholar 

  85. 85.

    G. S. Omenn, G. E. Goodman, and M. D. Thornquist, N. Engl. J. Med., 334, 1150–1155 (1996).

    CAS  PubMed  Article  Google Scholar 

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Correspondence to S. V. Pechinskii.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 10, pp. 3 – 8, October, 2013.

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Pechinskii, S.V., Kuregyan, A.G. The Impact of Carotenoids on Immunity (Review). Pharm Chem J 47, 509–513 (2014). https://doi.org/10.1007/s11094-014-0992-z

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Keywords

  • carotenoids
  • immune system