Skip to main content
SpringerLink
Log in

Synthesis and Antifungal Activity of Arylthiocyanates

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

A new method for the synthesis of arylthiocyanates from derivatives of aniline, pyrrole, and indole is described. Products had antimicrobial activity. Dithiocyanates N-methylpyrrole and N-phenylpyrrole were active against Candida albicans, Candida tropicalis, Candida krusei, and Aspergillus niger with activity levels comparable to those of fluconazole and amphotericin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. D. J. Sullivan, G. P. Moran, D. C. Coleman, et al., Fungi. Biology and Applications, K. Kavanagh (ed.), John Wiley & Sons, New York (2011).

  2. B. Park, T. Chiller, M. Brandt, and D. Warnock, “Epidemiology of systemic fungal diseases: an overview,” in: Essentials of Clinical Mycology, C. A. Kauffman, P. G. Pappas, J. D. Sobel and W. E. Dismukes (eds.), Springer, New York (2011), pp. 27 – 37.

    Chapter  Google Scholar 

  3. Dutch patent No. 6617755; URL: http://worldwide.espacenet.com (viewed on 07.04.2013).

  4. H. Dolman, A. Tempel, H. Koopman, et al., Recueil des Travaux Chimiques des Pays-Bas, 38(4), 417 – 425 (1969).

    Google Scholar 

  5. F. Pavanetto, L. Montanari, T. Modena, Farmaco Sci., 40(8), 576 – 580 (1985).

    CAS  PubMed  Google Scholar 

  6. P. I. Yagodinets, O. V. Skripskaya, N. G. Prodanchuk, et al., Khim.-Farm. Zh., 29(1), 49 – 51 (1995).

    CAS  Google Scholar 

  7. N. S. Raduloviæ, M. S. Dekiæ, Z. Z. Stojanoviæ-Radiæ, Phytochem. Lett., 52, 351 – 357 (2012).

    Article  Google Scholar 

  8. US patent No. 2433106; URL: http://worldwide.espacenet.com (viewed on 07.04.2013).

  9. US patent No. 6130224; URL: http://worldwide.espacenet.com (viewed on 07.04.2013).

  10. T. Nagamachi, J. L. Fourrey, P. F. Torrence, et al., J. Med. Chem., 17(4), 403 – 406 (1974).

    Article  CAS  PubMed  Google Scholar 

  11. P. Herdewijn, J. Balzarini, E. De Clercq, et al., J. Med. Chem., 30(8), 1270 – 1278 (1987).

    Article  CAS  PubMed  Google Scholar 

  12. E. Elhalem, B. N. Bailey, R. Docampo, et al., J. Med. Chem., 45(18), 3984 – 3999 (2002).

    Article  CAS  PubMed  Google Scholar 

  13. R. G. Guy. “Syntheses and preparative applications of thiocyanates,” in: Cyanates and their Thio Derivatives, S. Patai (ed.), John Wiley & Sons, New York (1977), Vol. 2, pp. 819 – 886.

  14. N. A. Semina, S. V. Sidorenko, S. P. Rezvan, et al., Klin. Mikrobiol. Antimikrob. Khimioter., 6(4), 306 – 359 (2004).

    Google Scholar 

  15. Approved Standard: M7-A7. Methods for Dilution. Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, Clinical and Laboratory Standards Institute, CLSI, Wayne, Pa, 7th ed., (2006).

  16. Approved Standard: M27-A3. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts, Clinical and Laboratory Standards Institute, CLSI, Wayne, Pa, 3rd ed. (2008).

Download references

Author information

Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

    V. A. Kokorekin, A. O. Terent’ev & A. I. Ilovaiskii

  2. First I. M. Sechenov Moscow State Medical University, Moscow, Russia

    V. A. Kokorekin, G. V. Ramenskaya, N. É. Grammatikova & G. M. Rodionova

  3. State Scientific Center for Antibiotics, Moscow, Russia

    N. É. Grammatikova

Authors
  1. V. A. Kokorekin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. O. Terent’ev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. V. Ramenskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. É. Grammatikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. M. Rodionova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. I. Ilovaiskii
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. A. Kokorekin.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 8, pp. 26 – 29, August, 2013.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kokorekin, V.A., Terent’ev, A.O., Ramenskaya, G.V. et al. Synthesis and Antifungal Activity of Arylthiocyanates. Pharm Chem J 47, 422–425 (2013). https://doi.org/10.1007/s11094-013-0973-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-013-0973-7

Keywords

Search

Navigation