Skip to main content
SpringerLink
Log in

Synthesis and Analgesic Activity of 3,3-Dialkylsubstituted 3,4-Dihydroisocarbostyryls

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

New isoquinolin-1-one derivatives were prepared. These compounds had low toxicity and marked influences on motor and investigative activity in mice. Compound 3,3-pentamethylene-3,4-dihydroisoquinolin-1-one had central analgesic activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. B. B. Aleksandrov, M. Yu. Dormidontov, V. S. Shklyaev, and Yu. V. Shklyaev, Khim. Geterotsikl. Soedin., No. 7, 995 (1990).

  2. Yu. V. Shklyaev and Yu. V. Nifontov, Izv. Akad. Nauk. SSSR Ser. Khim., No. 5, 780–784 (2001).

  3. Yu. V. Shklyaev, V. A. Glushkov, N. B. Belogub, et al., Khim. Geterotsikl. Soedin., No. 6, 800–806 (1996).

  4. Yu. V. Shklyaev, Yu. V. Nifontov, R. R. Ismagilov, et al., Butlerov Commun., No. 6, 67–70 (2002).

  5. V. B. Prozorovskii, M. P. Prozorovskaya, and V. M. Demchenko, Farmakol. Toksikol., 4, 497–502 (1978).

    Google Scholar 

  6. N. B. Eddy, D. Leimbach, J. Pharmacol. Exp. Ther., 107(3), 385–393 (1953).

    CAS  Google Scholar 

  7. R. D. Syubaev, M. D. Mashkovskii, G. Ya. Shvarts, and V. I. Pokryshkin, Khim.-Farm. Zh., 19(1), 33–39 (1985).

    Google Scholar 

  8. R. Koster, M. Anderson, and E. J. de Beer, Fed. Proc., 18(7), 412 (1959).

    Google Scholar 

  9. I. R. Bossier, P. Simon, I. M. Zwolf, Therapie, 19(3), 571–583 (1964).

    Google Scholar 

  10. M. L. Belen’kii, Elements of the Measurement of Pharmacological Effects [in Russian], Meditsinskaya Literature, Leningrad (1963).

    Google Scholar 

  11. Yu. B. Vikharev, L. V. Anikina, Yu. V. Shklyaev, et al., Farm. Zh., 39(8), 13–15 (2005).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Technical Chemistry, Urals Division, Russian Academy of Sciences, Perm, Russia

    L. V. Anikina, Yu. B. Vikharev, A. A. Gorbunov & Yu. V. Shklyaev

Authors
  1. L. V. Anikina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu. B. Vikharev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. A. Gorbunov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yu. V. Shklyaev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yu. V. Shklyaev.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 8, pp. 23 – 25, August, 2013.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Anikina, L.V., Vikharev, Y.B., Gorbunov, A.A. et al. Synthesis and Analgesic Activity of 3,3-Dialkylsubstituted 3,4-Dihydroisocarbostyryls. Pharm Chem J 47, 419–421 (2013). https://doi.org/10.1007/s11094-013-0972-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-013-0972-8

Keywords

Search

Navigation