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Compatibility of a stable emulsion based on perfluorocarbons and phospholipids with various blood substitutes

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

The influence of various blood substitutes on the physicochemical parameters of stable emulsions based on perfluorocarbons (PFCs) and phospholipids (PhLs) was studied. The particle structure, size, and surface properties in the emulsions did not change upon mixing with blood substitutes (0.9% NaCl, mafusol, polyoxidine, polyoxifumarin, and refortan). The relative viscosities of all mixed media did not exceed the values of this parameter for blood plasma. It was suggested that the PFC/PhL emulsion would perform in vivo a gas-transport function and would not produce negative effects on the blood viscosity.

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Authors and Affiliations

  1. State Research Institute of Hematology and Transfusiology, St. Petersburg, 191024, Russia

    I. N. Kuznetsova, V. S. Yurchenko & G. A. Kochetkova

Authors
  1. I. N. Kuznetsova
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  2. V. S. Yurchenko
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  3. G. A. Kochetkova
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Correspondence to I. N. Kuznetsova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 6, pp. 25 – 29, June, 2013.

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Kuznetsova, I.N., Yurchenko, V.S. & Kochetkova, G.A. Compatibility of a stable emulsion based on perfluorocarbons and phospholipids with various blood substitutes. Pharm Chem J 47, 310–314 (2013). https://doi.org/10.1007/s11094-013-0950-1

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  • DOI: https://doi.org/10.1007/s11094-013-0950-1

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