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Synthesis and Antitumor and Antibacterial Properties of New N-Alkylated Pyrimidines

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Pharmaceutical Chemistry Journal Aims and scope

Uracil and 5-fluoro-, -bromo-, and -iodouracils were alkylated by substituted benzylchlorides to obtain N1-mono- and N 1,N 3-bis-substituted derivatives. The toxicity, antitumor, and antibacterial properties of the synthesized compounds were investigated. It was established that 5-fluoro- and 5-iodouracils exhibited more pronounced antitumor properties than 5-bromouracil derivatives.

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Authors and Affiliations

  1. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, 375014, Armenia

    A. A. Arutyunyan, H. M. Stepanyan & R. V. Paronikyan

  2. Molecular Structure Research Center, National Academy of Sciences of Armenia, 0014, Yerevan, 375014, Armenia

    S. S. Mamyan

Authors
  1. A. A. Arutyunyan
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  2. S. S. Mamyan
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  3. H. M. Stepanyan
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  4. R. V. Paronikyan
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Corresponding author

Correspondence to A. A. Arutyunyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 6, pp. 19 – 21, June, 2013.

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Arutyunyan, A.A., Mamyan, S.S., Stepanyan, H.M. et al. Synthesis and Antitumor and Antibacterial Properties of New N-Alkylated Pyrimidines. Pharm Chem J 47, 303–306 (2013). https://doi.org/10.1007/s11094-013-0948-8

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  • DOI: https://doi.org/10.1007/s11094-013-0948-8

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