The ability of a water-soluble inclusion complex (KN-14-CD) of an aminomethylated dihydroquercetin derivative (KN-14) in β-cyclodextrin (CD) to inhibit ozone-induced oxidation of fibrinogen was evaluated. KN-14-CD prevented ozone-induced oxidation of fibrinogen and preserved its ability to form clots after the addition of thrombin. The ability of KN-14-CD to prevent oxidative modification of fibrinogen was more pronounced than that of native dihydroquercetin (taxifolin).
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. V. Karlina, O. N. Pozharitskaya, and A. N. Shikov, Khim.-farm. Zh., 43(6), 46 – 48 (2009).
V. S. Rogovskii, N. L. Shimanovskii, and A. I. Matyushin, Eksp. Klin. Farmakol., 75(9), 37 – 41 (2012).
E. B. Meh’shchikova, V. Z. Lankin, N. K. Zenkov, et al., Oxidative Stress. Pro-oxidants and Antioxidants [in Russian], Firma Slovo, Moscow (2006).
V. A. Kurkin, V. M. Ryzhov, O. V. Biryukova, et al., Khim.-farm. Zh., 43(2), 33 – 42 (2009).
V. S. Rogovsky, M. A. Rosenfeld, V. B. Leonova, et al., J. Information, Intelligence Knowledge, 4(1), 53 – 60 (2012).
I. P. Ivanova, D. I. Knyazev, and Yu. V. Kudryavtsev, Sovrem. Tekhnol. Med., No. 3, 16 – 20 (2011).
K. B. Pandey, N. Mishra, and S. I. Rizvi, Clin. Biochem., No. 43, 508 – 511 (2010).
C. Banfi, M. Brioschi, S. Barcella, et al., Eur. J. Heart Failure, 10, 244 – 251 (2008).
M. A. Rozenfel’d, V. B. Leonova, M. L. Konstantinova, and S. D. Razumovskii, Izv. Ross. Akad. Nauk, Ser. Biol., No. 6, 671 – 679 (2008).
L. C. Dijkgraaf, G. Zaardeneta, F. W. Corddewener, et al., J. Oral Maxillofac. Surg., No. 61, 101 – 111 (2003).
E. Shacter, J. A. Williams, and R. F. Levine, Free Radical Biol. Med., No. 18, 815 – 831 (1995).
M. A. Belisario, D. Domenico, C. Pelagalli, et al., Biochimie, No. 79, 449 – 455 (1997).
E. V. Roitman, O. A. Azizova, Yu. A. Morozov, and A. V. Aseichev, Byull. Eksp. Biol. Med., No. 138, 527 – 530 (2004).
M. A. Rozenfel’d, V. B. Leonova, A. N. Shchegolikhin, et al., Biokhimiya, 75(10), 1451 – 1461 (2010).
O. A. Azizova, E. V. Maksyanina, Yu. A. Romanov, et al., Byull. Eksp. Biol. Med., No. 137, 406 – 409 (2004).
V. I. Lushchak, Biokhimiya, No. 72, 995 – 1017 (2007).
O. A. Azizova, A. V. Aseichev, A. P. Piryazev, and L. V. Shulenina, Byull. Eksp. Biol. Med., No. 3, 284 – 290 (2009).
RU Pat. 2,396,077 (2009), Aug. 10, 2010; Ref. Zh. Khim., A61P9 / 14 (2009).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 47, No. 6, pp. 10 – 13, June, 2013.
Rights and permissions
About this article
Cite this article
Rogovsky, V.S., Arzamasova, T.M., Rosenfel’d, M.A. et al. Effect of an Inclusion Complex of an Aminomethylated Dihydroquercetin Derivative in Cyclodextrin on Ozone-Induced Oxidation of Fibrinogen. Pharm Chem J 47, 295–298 (2013). https://doi.org/10.1007/s11094-013-0946-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-013-0946-x