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Synthesis and radioprotector activity of N-vinylpyrrolidone and 2-methyl-5-vinyltetrazole copolymers

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Pharmaceutical Chemistry Journal Aims and scope

Copolymers of N-vinylpyrrolidone and 2-methyl-5-vinyltetrazole with various ratios of monomer units were synthesized by radical polymerization using the injection method. The copolymerization parameters for these monomers were calculated by the Kelen―Tudos method (r1 = 14.34; r2 = 0.06) for high degrees of conversion. Copolymers with monomer-unit concentrations up to 70 ± 5 mol% were soluble in water, non-toxic, and effective as radioprotectors.

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Authors and Affiliations

  1. Lomonosov Moscow State University of Fine Chemical Technology, Moscow, Russia

    S. A. Kedik, Yu. V. Kochkina (Cherta), D. V. Eremin & A. V. Panov

  2. Institute of Pharmaceutical Technology, Moscow, 119571, Russia

    S. A. Kedik, Yu. V. Kochkina (Cherta), D. V. Eremin, A. V. Panov & V. V. Suslov

  3. State Scientific Center for Drug Expertise and Control, Ministry of the Russian Federation for Public Health, Moscow, Russia

    I. V. Sakaeva

Authors
  1. S. A. Kedik
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  2. I. V. Sakaeva
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  3. Yu. V. Kochkina (Cherta)
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  4. D. V. Eremin
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  5. A. V. Panov
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  6. V. V. Suslov
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Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 46, No. 12, pp. 30–33, December, 2012.

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Kedik, S.A., Sakaeva, I.V., Kochkina (Cherta), Y.V. et al. Synthesis and radioprotector activity of N-vinylpyrrolidone and 2-methyl-5-vinyltetrazole copolymers. Pharm Chem J 46, 726–729 (2013). https://doi.org/10.1007/s11094-013-0879-4

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  • DOI: https://doi.org/10.1007/s11094-013-0879-4

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