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Synthesis and Antimicrobial Activity of N,6-Diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

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N,6-Diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides were synthesized by a three-component reaction of acetoacetanilides (2,4-dimethylacetoacetanilide, o-acetoacetaniside, 2-chloroacetoacetanilide), aromatic aldehydes, and urea. The structures of the products were established by IR and PMR spectroscopy and mass spectrometry. The antimicrobial activity of the synthesized compounds was studied.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Perm, Russia

    V. L. Gein, A. Yu. Fedotov, T. M. Zamaraeva, A. A. Bobyleva, N. N. Kasimova & T. F. Odegova

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  1. V. L. Gein
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  2. A. Yu. Fedotov
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  3. T. M. Zamaraeva
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  4. A. A. Bobyleva
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  5. N. N. Kasimova
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  6. T. F. Odegova
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Additional information

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 46, No. 12, pp. 24–26, December, 2012.

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Gein, V.L., Fedotov, A.Y., Zamaraeva, T.M. et al. Synthesis and Antimicrobial Activity of N,6-Diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Pharm Chem J 46, 720–722 (2013). https://doi.org/10.1007/s11094-013-0877-6

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  • DOI: https://doi.org/10.1007/s11094-013-0877-6

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