Water-soluble compounds were prepared by the reaction of α-oxocarboxylic acids with heterocyclic amines and the reaction of 2-(2-hydroxyphenyl)-2-oxoethanoic acid with sodium carbonate. Their effects on the blood coagulation system were studied. Compounds with high anticoagulant activity were identified.
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Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 46, No. 12, pp. 15–18, December, 2012.
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Pulina, N.A., Sobin, F.V., Syropyatov, B.Y. et al. Synthesis and Anticoagulant Activity of α-Oxocarboxylic Acid Derivatives. Pharm Chem J 46, 711–714 (2013). https://doi.org/10.1007/s11094-013-0875-8
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DOI: https://doi.org/10.1007/s11094-013-0875-8