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Drugs for the treatment of overactive bladder syndrome: present and future (A Review)

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Pharmaceutical Chemistry Journal Aims and scope

Published data concerning drugs currently used for the treatment of overactive bladder (OAB) syndrome were reviewed. Modern notions about the physiology and pathophysiology of micturition were considered and data on the pharmacological properties, tolerance, and therapeutic efficiency of anticholinergic drugs (antimuscarinic agents), the first-line drugs for treating OAB, were presented. Data on drugs with a different mechanism of action that are currently used to treat OAB were reviewed. Information on the principal directions of new drug development, in particular, β3-adrenoreceptor agonists, compounds affecting KCNQ/Kv7-channels, vitamin D receptors, etc., was summarized.

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Authors and Affiliations

  1. Sechenov First Moscow State Medical University, Moscow, 119991, Russia

    G. Ya. Shvarts

  2. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, 125367, Russia

    P. G. Shvarts, A. N. Plotnikov & D. Yu. Savvin

Authors
  1. G. Ya. Shvarts
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  2. P. G. Shvarts
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  3. A. N. Plotnikov
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  4. D. Yu. Savvin
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 12, pp. 3–10, December, 2012.

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Shvarts, G.Y., Shvarts, P.G., Plotnikov, A.N. et al. Drugs for the treatment of overactive bladder syndrome: present and future (A Review). Pharm Chem J 46, 699–706 (2013). https://doi.org/10.1007/s11094-013-0873-x

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  • DOI: https://doi.org/10.1007/s11094-013-0873-x

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