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Application of HPLC to the Analysis of Benzethonium Chloride in Eye Drops

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Pharmaceutical Chemistry Journal Aims and scope

The possibility of using mobile phases with ion-pairing reagents for HPLC determination of benzethonium chloride in eye drops was studied. The most suitable mobile phases among those studied were acetonitrile:aqueous tetrabutylammonium hydrophosphate (5 mM) (65:35) and acetonitrile:aqueous tetrabutylammonium hydrophosphate (2.5 mM) and sodium heptanesulfonate (2.5 mM) (65:35). The most efficient chromatography columns for the benzethonium peak were Zorbax SB C8 (150 × 4.6 mm, 3.5 μm) and Diaspher-110-Phenyl (150 × 4.6 mm, 5 μm).

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References

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Authors and Affiliations

  1. State Scientific Center for Drug Expertise and Control, Ministry of the Russian Federation for Public Health, Moscow, Russia

    A. S. Osipov

  2. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russia

    E. N. Orlov

Authors
  1. A. S. Osipov
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  2. E. N. Orlov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 11, pp. 41 – 43, November, 2012.

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Osipov, A.S., Orlov, E.N. Application of HPLC to the Analysis of Benzethonium Chloride in Eye Drops. Pharm Chem J 46, 684–686 (2013). https://doi.org/10.1007/s11094-013-0870-0

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  • DOI: https://doi.org/10.1007/s11094-013-0870-0

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