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Gel chromatographic and toxicological studies of the mechanochemical transformations of water-soluble polysaccharides

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Pharmaceutical Chemistry Journal Aims and scope

Changes in the molecular weight characteristics of polysaccharide macromolecules - arabinogalactan, hydroxyethyl starch 200/0.5, Fibregum, and dextrans 10, 40, and 70 - were studied during mechanochemical processing. A preference for “gentle” conditions for mechanical processing (~1 g) were established, as these conditions do not lead to destruction of polysaccharide macromolecules. An additional advantage of these mechanical processing regimes is that they can be scaled up to industrial flow mills. Mechanochemical processing had no adverse effect on the toxicity measures of the polysaccharides studied. Toxicological studies of mechanically processed arabinogalactan, hydroxyethyl starch 200/0.5, Fibregum, and dextrans 10, 40, and 70 showed that these polysaccharides and the products of their mechanochemical processing can be classified as class 4 (low-toxicity) substances.

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Authors and Affiliations

  1. Institute of Solid State Chemistry and Mechanochemistry (ISSCM), Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    A. V. Dushkin & E. S. Meteleva

  2. Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    T. G. Tolstikova, A. V. Pavlova & M. V. Khvostov

Authors
  1. A. V. Dushkin
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  2. E. S. Meteleva
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  3. T. G. Tolstikova
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  4. A. V. Pavlova
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  5. M. V. Khvostov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 10, pp. 53 – 56, October, 2012.

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Dushkin, A.V., Meteleva, E.S., Tolstikova, T.G. et al. Gel chromatographic and toxicological studies of the mechanochemical transformations of water-soluble polysaccharides. Pharm Chem J 46, 630–633 (2013). https://doi.org/10.1007/s11094-013-0859-8

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  • DOI: https://doi.org/10.1007/s11094-013-0859-8

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