An original in vitro two-phase model was proposed for evaluating the dissolution of hydrophobic compounds from oral lozenges. The new model was used for biopharmaceutical evaluation of lozenges with coenzyme Q10. The mechanism of drug release was determined. The main pharmacokinetic parameters of coenzyme Q10 in tablets studied in vivo and in vitro were compared in order to check the adequacy of the proposed model. A correlation of power A (r = 0.8991) between drug release and pharmacokinetic parameters was found and provided the correct prognosis of the experimental pharmacokinetic profile of coenzyme Q10 according to its release rate. This confirmed the validity of the proposed in vitro model.
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References
M. Balamurugan, V. S. Saravanan, P. Ganesh, et al., Res. J. Pharm. Technol., 1(4), 377 – 380 (2008).
D. Harris and J. R. Robinson, J. Pharm. Sci., 81(1), 1 – 10 (1992).
USP 32 / NF 27, General Chapter 724, Drug Release, Convention Inc., Rockville (2009), p. 272.
European Pharmacopoeia 6, Pharmaceutical Technical Procedure, 2.9.3. Dissolution test for solid dosage forms. European Directorate for the Quality of Medicines & Healthcare (2007), pp. 266 – 275.
M. V. Karlina, V. M. Kosman, O. N. Pozharitskaya, et al., Khim.-farm. Zh., 46(4), 42 – 45 (2012).
V. K. Piotrovskii, Farmakol. Toksikol., 49(5), 118 – 127 (1986).
S. O. Klyuchnikov and E. S. Gnetneva, Pediatriya, 87(3), 103 – 110 (2008).
O. I. Corrigan, Adv. Exp. Med. Biol., 423, 111 – 128 (1997).
Human metabolome database, URL: http://www.hmdb.ca/metabolites/hmdb01072 (accessed May 23, 2011).
General pharmacopoeial article (OFS) 42-0003-04 “Dissolution” (2004).
E. V. Velikaya, V. A. Kemenova, and N. B. Demina, Khim.-farm. Zh., 38(5), 38 – 41 (2004).
M. V. Karlina, O. N. Pozharitskaya, and V. M. Kosman, Vopr. Biol. Med. Farm. Khim., 9(3), 42 – 46 (2006).
L. F. Sidel?nikova, S. M. Zakharova, and Zh. I. Rakhnii, Sovrem. Stomatol., 2(51), 44 – 49 (2010).
G. Frenning, E. K. Rganar, and M. Stromme, J. Pharm. Sci., 91(3), 776 – 784 (2002).
P. Costa and J. M. Sousa Lobo, Drug. Dev. Ind. Pharm., 29(1), 89 – 97 (2003).
H. K. Raslan and H. Maswadeh, Indian J. Pharm. Sci., 68, 308 – 312 (2006).
J. Emami, J. Pharm. Pharm. Sci., 9(1), 82 – 100 (2006).
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The work was supported financially by Pharmasoft Co., Russia.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 7, pp. 52 – 55, July, 2012.
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Karlina, M.V., Pozharitskaya, O.N., Kosman, V.M. et al. An in vitro model for evaluation of the release rate of hydrophobic compounds from coenzyme Q10 lozenges and in vivo/in vitro correlation. Pharm Chem J 46, 456–459 (2012). https://doi.org/10.1007/s11094-012-0820-2
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DOI: https://doi.org/10.1007/s11094-012-0820-2