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Synthesis and characterization of polysulfanilamide and its copolymers: bioactivity and drug release

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Pharmaceutical Chemistry Journal Aims and scope

An Erratum to this article was published on 01 November 2012

Sulfanilamide reacted with acryloyl chloride to give 4-(N-acrylamido)benzenesulfonamide (ABA), which converted to the corresponding polymer (PABA) upon treatment with initiator at 75°C. Various copolymers formed from ABA with acrylamide (AA), acrylonitrile (AN), and N-(thiazol-2-yl)acrylamide (TA) at different ratios (50 : 50, 70 : 30 and 30 : 70) were prepared. The polymer and copolymers were characterized using IR, 1H NMR, 13C NMR and mass spectroscopy, thermogravimetry, and scanning electron microscopy. The drug release from polymeric chain and copolymers was studied at 37°C and pH 8.4. The drug release was highly increased upon adding sodium chloride at various concentrations, 0.1%, 0.5% and 0.9%. The drug release from the polymer and copolymer chains was measured using a UV-visible spectroscopy technique. Antimicrobial activity of the polymer and copolymers was studied. It is established that the ABA copolymer with TA is more effective as compared to other copolymers.

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Acknowledgements

The authors are grateful to the Public Authority for Applied Education and Training for funding. The authors are also grateful to Kuwait University, Chemistry Department, and Faculty of Science for SAF facilities project GS01/03 and GS03/01.

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Authors and Affiliations

  1. Pharmaceutical Science Department, College of Health Science, The Public Authority for Applied Education and Training, Adailiyah, Kuwait

    Abdulhakeem Alsughayer

  2. Chemistry Department, Faculty of Science, Kuwait University, P. O. Box 5969, Safat, 13060, Kuwait

    Abdel-Zaher A. Elassar, Fakhreia Al Sagheer & Seham Mustafa

Authors
  1. Abdulhakeem Alsughayer
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  2. Abdel-Zaher A. Elassar
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  3. Fakhreia Al Sagheer
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  4. Seham Mustafa
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Correspondence to Abdel-Zaher A. Elassar.

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Alsughayer, A., Elassar, AZ.A., Al Sagheer, F. et al. Synthesis and characterization of polysulfanilamide and its copolymers: bioactivity and drug release. Pharm Chem J 46, 418–428 (2012). https://doi.org/10.1007/s11094-012-0813-1

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  • DOI: https://doi.org/10.1007/s11094-012-0813-1

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