A series of new sterically hindered alkylsulfonate-and adamantane-N-substituted o-aminophenol derivatives were synthesized. The antiviral properties of these compounds were studied in cell culture against Herpes simplex type-1 (HSV-1) and influenza A (H7N1) viruses. The ability of many compounds (8 of 13, 61.5%) to suppress replication of HSV-1 was established. Among the tested compounds, N-(2-hydroxy-3,5-diisopropylphenyl)benzenesulfonamide displayed the highest activity in suppressing replication of HSV-1 virus.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 7, pp. 27-30, July, 2012.
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Shadyro, O.I., Sorokin, V.L., Ksendzova, G.A. et al. Synthesis and antiviral activity of sterically hindered o-aminophenol derivatives. Pharm Chem J 46, 414–417 (2012). https://doi.org/10.1007/s11094-012-0812-2
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DOI: https://doi.org/10.1007/s11094-012-0812-2