Reactions of 4,6-dihydrazino-5-nitro- and 2-methylthio-4-hydrazino-6-chloro-5-(p-alkoxybenzyl)pyrimidines with carbonyl compounds and aryl- and cyclohexylisothiocyanates were studied. The influence of the products on DNA methylation and their in vitro antitumor properties were studied.
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J. V. Garibyan (Deceased).
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 7, pp. 15 – 18, July, 2012.
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Grigoryan, L.A., Kaldrikyan, M.A., Melik-Ogandzhanyan, R.G. et al. Synthesis of pyrimidylhydrazones and substituted pyrimidyl-aryl- and –yclohexylthiosemicarbazides and study of their influence on DNA methylation. Pharm Chem J 46, 402–405 (2012). https://doi.org/10.1007/s11094-012-0809-x
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DOI: https://doi.org/10.1007/s11094-012-0809-x