A procedure for the spectrophotometric quantification of thiosens in a new lyophilized liposomal drug form containing lecithin, cholesterol, and PEG-2000-DSPE at a molar ratio of 1:0.22:0.002 in addition to sucrose solution (cryoprotector) at a lecithin:cryoprotectant mass ratio of 1:2 was developed. The influence of excipients on the analytical results and the observance of the Bouguer–Lambert–Beer law was evaluated.
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The work was carried out in the framework of the scientific technical program “Development and Practical Implementation in Health of New Methods and Agents for Prevention, Diagnosis, and Treatment of Oncological, Infectious, and Other Serious Diseases” that was financed by the Moscow Government.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 6, pp. 54 – 56, June, 2012.
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Sanarova, E.V., Polozkova, A.P., Meerovich, I.G. et al. Quantitative determination of thiosens in a new liposomal drug form. Pharm Chem J 46, 386–388 (2012). https://doi.org/10.1007/s11094-012-0805-1
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DOI: https://doi.org/10.1007/s11094-012-0805-1