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Piroxicam ex vivo release kinetics from zein/pectin delivery systems

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Pharmaceutical Chemistry Journal Aims and scope

Piroxicam ex vivo release kinetics from zein/pectin drug delivery systems were studied using rat cecum. The piroxicam release kinetic parameters were calculated using a first-order equation and the Peppas equation. The results indicated that diffusion of the therapeutic agent was the rate-limiting step in piroxicam release from the hydrogel microspheres. The created therapeutic drug forms based on biodegradable polymers were an alternative to the peroral administration of most drugs with limited bioavailability.

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References

  1. L. S. Liu, M. L. Fishman, K. B. Hicks, et al., Drug Delivery, 13, 417 – 423 (2006).

    Article  PubMed  CAS  Google Scholar 

  2. G. F. Kasymova, D. T. Bobokalonov, A. S. Nasriddinov, et al., Izv. Akad. Nauk Resp. Tadzh. Otd. Fiz.-Mat., Khim. Geol. Nauk, 134(1), 59 – 65 (2009).

    Google Scholar 

  3. Z. K. Mukhidinov, G. F. Kasymova, D. T. Bobokalonov, et al., Khim.-farm. Zh., 44(9), 20 – 24 (2010).

    Google Scholar 

  4. G. F. Kasymova, D. T. Bobokalonov, M. D. Khalikova, et al., Izv. Akad. Nauk Resp. Tadzh. Otd. Fiz.-Mat., Khim. Geol. Nauk, 127(2), 42 – 50 (2007).

    Google Scholar 

  5. Guide for the Care and Use of Laboratory Animals, National Academy Press, Washington, D. C. (1996).

  6. A. Sh. Shtanchaev, A. S. Nasriddinov, Kh. I. Teshaev, et al., Dokl. Akad. Nauk Resp. Tadzh., 50, 725 – 730 (2007).

    Google Scholar 

  7. T. Higuchi, J. Pharmacol. Sci., 52, 1145 – 1148 (1960).

    Google Scholar 

  8. R. W. Korsmeyer, S. R. Lustig, and N. A. Peppas, J. Polym. Sci., Part B: Polym. Phys., 24, 395 – 408 (1986).

    Article  CAS  Google Scholar 

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Acknowledgments

The work was carried out under the auspices of ISTC Project T-1419 and was financed by the USDA.

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Authors and Affiliations

  1. Nikitin Institute of Chemistry, Tajik Academy of Sciences, Dushanbe, 834063, Tajikistan

    D. T. Bobokalonov, Z. K. Mukhidinov, I. F. Rakhimov, F. M. Khodzhaeva & G. F. Kasymova

  2. Eastern Regional Research Center ARS USDA, 600 East Mermaid Lane, Wyndmoor, PA, 19038, USA

    L. S. Liu

Authors
  1. D. T. Bobokalonov
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  2. Z. K. Mukhidinov
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  3. I. F. Rakhimov
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  4. F. M. Khodzhaeva
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  5. G. F. Kasymova
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  6. L. S. Liu
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 6, pp. 51 – 53, June, 2012.

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Bobokalonov, D.T., Mukhidinov, Z.K., Rakhimov, I.F. et al. Piroxicam ex vivo release kinetics from zein/pectin delivery systems. Pharm Chem J 46, 378–380 (2012). https://doi.org/10.1007/s11094-012-0803-3

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  • DOI: https://doi.org/10.1007/s11094-012-0803-3

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