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Isolation, identification, and nootropic activity of compounds in Alfredia cernua chloroform extract

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Pharmaceutical Chemistry Journal Aims and scope

The chemical composition of the CHCl3 fraction of the total extract (95% EtOH) of Alfredia cernua (L.) Cass aerial part included triterpene alcohols (α-amyrin, β-amyrin, moretenol, lupeol) and butyrolignan (arctiin) in addition to various simple phenols and organic acids and their esters. It was established that the triterpene alcohols and arctiin demonstrated marked nootropic activity that was comparable with that of the whole CHCl3 fraction.

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Acknowledgments

We thank Dr. Elvira E. Shults, Head of the Medicinal Chemistry Laboratory, Novosibirsk Institute of Organic Chemistry, SB, RAS, for help in organizing the analytical studies and for discussion of the results.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia

    I. V. Shilova, N. I. Suslov & R. N. Mustafin

  2. Irkutsk State Technical University, Irkutsk, Russia

    A. A. Semenov

  3. Krasnoyarsk State Medical University, Krasnoyarsk, Russia

    N. V. Kuvacheva

Authors
  1. I. V. Shilova
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  2. A. A. Semenov
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  3. N. V. Kuvacheva
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  4. N. I. Suslov
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  5. R. N. Mustafin
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 6, pp. 36 – 41, June, 2012.

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Shilova, I.V., Semenov, A.A., Kuvacheva, N.V. et al. Isolation, identification, and nootropic activity of compounds in Alfredia cernua chloroform extract. Pharm Chem J 46, 363–368 (2012). https://doi.org/10.1007/s11094-012-0799-8

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  • DOI: https://doi.org/10.1007/s11094-012-0799-8

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