A series of new analogs of 2-arylpyrrolidinecarbonitriles were synthesized under phase-transfer catalysis conditions. New analogs of pyrrolidinecarboxamides were synthesized based on these carbonitriles. Biological evaluation showed that the synthesized derivatives of pyrrolidinecarbonitriles and pyrrolidinecarboxamides possessed moderate anticancer activity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 6, pp.9–11, June, 2012.
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Gasparyan, S.P., Alexanyan, M.V., Arutyunyan, G.K. et al. Synthesis and biological properties of new derivatives of 2-arylpyrrolidinecarbonitriles and pyrrolidinecarboxamides. Pharm Chem J 46, 331–333 (2012). https://doi.org/10.1007/s11094-012-0792-2
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DOI: https://doi.org/10.1007/s11094-012-0792-2