The synthesis of 10-chloroethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazole was described. The nucleophilic substitution of the chlorine atom by various amines was studied. As a result, 10-alkylaminoethyl-substituted derivatives of this tricycle containing alkylamines and 4-substituted piperazines were obtained. These compounds exhibited 5-HT2 antagonist activity; platelet antiaggregant properties; and moderate P2Y1-antagonist, antiarrhythmic, and hypoglycemic action.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 6, pp.3–8, June, 2012.
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Anisimova, V.A., Tolpygin, I.E., Spasov, A.A. et al. Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles. Pharm Chem J 46, 325–330 (2012). https://doi.org/10.1007/s11094-012-0791-3
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DOI: https://doi.org/10.1007/s11094-012-0791-3