Skip to main content
SpringerLink
Log in

Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Some aspects of the synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with the antituberculosis drug capreomycin sulfate are considered in this work. Polyethyl cyanoacrylate nanoparticles containing capreomycin sulfate have been synthesized using anionic polymerization in emulsion. Optimum conditions of immobilization of the drug into the polymeric matrix have been found. It was determined that to increase the loading efficiency of the drug, it has to be added into the reaction medium after polymerization has started.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Soppimath S. Kumaresh, Aminabhavi M. Tejrai, Kulkarni R. Anadrao, Rudzinskii E. Walter, J. Control. Rel., 70, 1 – 20 (2001).

    Article  Google Scholar 

  2. Ch. Vauthier, D. Labarre, G. Ponchel, J. Drug Target, 15(10), 641 – 663 (2007).

    Article  PubMed  CAS  Google Scholar 

  3. Ch. Vauthier, C. Dubernet, E. Fattal, et al., Advanced Drug Del. Rev., 55, 519 – 548 (2003).

    Article  CAS  Google Scholar 

  4. J. Kreuter, Nanoparticles: Colloidal Drug Delivery Systems, Marcel Dekker, New York (1994), pp. 223 – 228.

    Google Scholar 

  5. A. Bootz, T. Russ, F. Gores, et al., Eur. J. Pharm. Biopharm., 60, 391 – 399 (2005).

    Article  PubMed  CAS  Google Scholar 

  6. I. Kopecek, J. all-USSR Chem. Society named after D. I. Mendeleev, 30(4), 372 – 377 (1985).

    CAS  Google Scholar 

  7. M.-E. Page-Clisson, H. Pinto-Alphandary, M. Ourevitch, et al., J. Control. Rel., 56, 23 – 32 (1998).

    Article  CAS  Google Scholar 

  8. M. Simeonova, R. Velichkova, G. Ivanova, et al., Int. J. Pharm., 263, 133 – 140 (2003).

    Article  PubMed  CAS  Google Scholar 

  9. M. Simeonova, G. Ivanova, V. Enchev, et al., Acta Biomateria, 5, 2109 – 2121 (2009).

    Article  CAS  Google Scholar 

  10. Cariline O. Sullivan, C. Birkinshaw, Biomaterials, 25, 4375 – 4382 (2004).

    Article  PubMed  CAS  Google Scholar 

  11. E. V. Shipulo, I. I. Lyubimov, O. O. Maximenko, Khim-Farm. Zh., 38(3), 43 – 47 (2004).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Academician E. A. Buketov Karaganda State University, Universitetskaya street, 28, 100028, Karaganda, Kazakhstan

    L. Zh. Zhaparova, Y. M. Tazhbayev, M. Zh. Burkeev, A. T. Kazhmuratova & T. S. Zhumagaliyeva

  2. Eindhoven University of Technology, 5612 AZ, Eindhoven, Den Dolech 2, The Netherlands

    Syed I. Ali & Alex M. van Herk

Authors
  1. L. Zh. Zhaparova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. M. Tazhbayev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Zh. Burkeev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. T. Kazhmuratova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. S. Zhumagaliyeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Syed I. Ali
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Alex M. van Herk
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 1, pp. 8 – 11, January, 2012.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhaparova, L.Z., Tazhbayev, Y.M., Burkeev, M.Z. et al. Synthesis and characterization of polyethyl cyanoacrylate nanoparticles loaded with capreomycin sulfate. Pharm Chem J 46, 6–9 (2012). https://doi.org/10.1007/s11094-012-0724-1

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-012-0724-1

Key words

Search

Navigation