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Optimization of the composition and production technology of cifelin stealth liposomes

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Pharmaceutical Chemistry Journal Aims and scope

Cifelin is a hydrophobic anticancer drug. It is recommended to use this drug in high doses in order to achieve a therapeutic effect. Unfortunately, this treatment leads to a number of side effects. Inclusion of the drug in stealth liposomes reduces the toxicity and ensures a long circulation of cifelin in the bloodstream. In this study, the optimum molar ratio of components (165:8:1) was found for liposomal membranes composed of phosphatidylcholine, cholesterol, and PEG-2000-DSPE, respectively. The possibilities of using liposome technology based on extrusion and sonication were compared. For cifelin liposomes with vesicle size about 150 ± 10 nm, an entrapment efficiency of 98.3 % was estimated after sterilizing filtration of the dispersion. The liposome composition was confirmed by thin-layer chromatography with a mobile phase consisting of butanol:glacial acetic acid:water (12:3:5).

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Authors and Affiliations

  1. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia

    E. A. Kotova, A. P. Polozkova & N. A. Oborotova

  2. Sechenov First Moscow State Medical University, Moscow, 119991, Russia

    T. V. Denisova & I. I. Krasnyuk

Authors
  1. E. A. Kotova
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  2. A. P. Polozkova
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  3. T. V. Denisova
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  4. I. I. Krasnyuk
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  5. N. A. Oborotova
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 12, pp. 37 – 40, December, 2011.

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Kotova, E.A., Polozkova, A.P., Denisova, T.V. et al. Optimization of the composition and production technology of cifelin stealth liposomes. Pharm Chem J 45, 746–749 (2012). https://doi.org/10.1007/s11094-012-0716-1

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  • DOI: https://doi.org/10.1007/s11094-012-0716-1

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