The optimum composition of a stable lyophilized liposomal formulation of tiosens is established and includes lecithin, cholesterol, and PEG-2000-DSPE in a molar ratio of 1:0.22:0.002 and sucrose solution as a cryoprotector in a 1:9 lecithin:cryoprotector weight ratio. The effects of sonication, homogenization, and filtration on the quality of the liposomal preparation were studied. The results of preliminary studies lead to a conclusion about the satisfactory storage stability of the liposome form of tiosens.
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Acknowledgments
The work was performed with financial support of the Moscow City Government under the auspices of the Scientific-Technical Program “Development and Practical Translation into Healthcare of New Methods and Agents for Prevention, Diagnosis, and Treatment of Oncological, Infectious, and Other Serious Diseases”.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 12, pp. 32 – 36, December, 2011.
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Sanarova, E.V., Polozkova, A.P., Meerovich, I.G. et al. Influence of processing factors on the quality of the liposomal form of the new photosensitizer tiosens. Pharm Chem J 45, 741–745 (2012). https://doi.org/10.1007/s11094-012-0715-2
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DOI: https://doi.org/10.1007/s11094-012-0715-2