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Synthesis and antitumor activity of new furyl-2-substituted 1,3,4-thiadiazoles and 1,2,4-triazoles

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A series of new furyl-2-substituted derivatives of 1,3,4-thiadiazole and 1,2,4-triaozle have been synthesized. The S-alkylation and aminomethylation of the latter leading to their 3-mercapto- and 2-aminomethylene-substituted derivatives have been studied. Results of antitumor activity testing of the synthesized compounds are presented and discussed.

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Authors and Affiliations

  1. Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, 0014, Armenia

    T. R. Ovsepyan, S. V. Grboyan, F. G. Arsenyan & R. G. Melik-Ogandzhanyan

Authors
  1. T. R. Ovsepyan
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  2. S. V. Grboyan
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  3. F. G. Arsenyan
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  4. R. G. Melik-Ogandzhanyan
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Corresponding author

Correspondence to R. G. Melik-Ogandzhanyan.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 12, pp. 3 – 6, December, 2011.

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Ovsepyan, T.R., Grboyan, S.V., Arsenyan, F.G. et al. Synthesis and antitumor activity of new furyl-2-substituted 1,3,4-thiadiazoles and 1,2,4-triazoles. Pharm Chem J 45, 705–708 (2012). https://doi.org/10.1007/s11094-012-0706-3

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  • DOI: https://doi.org/10.1007/s11094-012-0706-3

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