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Synthesis and antimicrobial activity of urea derivatives of (1S,2S)-2-AMINO-1-(4-nitrophenyl)-1,3-propanediol

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A series of urea derivatives were synthesized from (1S,2S)-2-amino-1-(4-nitrophenyl)-1,3-propanediol and their antimicrobial activity was studied. The compounds synthesized here showed the greatest levels of activity against strains of Bacillus cereus, Staphylococcus aureus, and Streptococcus haemolyticus.

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The authors would like to thank M. Fernand Leal, France for assistance with these studies and helping to assess the results.

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Authors and Affiliations

  1. University of the Auvergne, Clairmont-Ferrand, France

    M. Madesclaire

  2. Samara State Medical University, Samara, Russia

    S. Kh. Sharipova, A. V. Lyamin, A. A. Osipova, E. A. Botkin & Yu. V. Zaitseva

  3. Samara State University, Samara, Russia

    V. P. Zaitsev

Authors
  1. M. Madesclaire
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  2. S. Kh. Sharipova
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  3. A. V. Lyamin
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  4. A. A. Osipova
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  5. E. A. Botkin
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  6. Yu. V. Zaitseva
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  7. V. P. Zaitsev
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 11, pp. 20 – 22, November, 2011.

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Madesclaire, M., Sharipova, S.K., Lyamin, A.V. et al. Synthesis and antimicrobial activity of urea derivatives of (1S,2S)-2-AMINO-1-(4-nitrophenyl)-1,3-propanediol. Pharm Chem J 45, 668–670 (2012). https://doi.org/10.1007/s11094-012-0700-9

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  • DOI: https://doi.org/10.1007/s11094-012-0700-9

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