A series of 9-aryl-8-(2-thienyl)-4,9-dihydrotetrazolo[1′,5′-1,2]pyrimido[4,5-d]pyridazin-5(6H)-ones have been obtained by reaction of equivalent amounts of methyl esters of 7-aryl-6-(2-thienyl)-4,7-dihydrotetrazolo[1, 5-a]pyrimidine-5-carboxylic acids and hydrazine hydrate at 180–190°C in the absence of solvents. The structures of the synthesized compounds have been determined based on spectral data (PMR, IR, high-resolution mass spectrometry). The synthesized compounds were tested for antimicrobial activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. L. Gein, V. V. Mishunin, E. P. Tsyplyakova, et al., Khim.-farm. Zh., 43(12), 46–48 (2007).
V. L. Gein, L. F. Gein, E. P. Tsyplyakova, and O. S. Panova, Zh. Org. Khim., 43(9), 1386–1390 (2007).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 9, pp. 22–24, September, 2011.
Rights and permissions
About this article
Cite this article
Gein, V.L., Mishunin, V.V., Tsyplyakova, E.P. et al. Synthesis and antifungal activity of 9-aryl-8-(2-thienyl)-4,9-dihydrotetrazolo-[1′,5′-1,2]pyrimido[4,5-d]pyridazin-5(6 h)-ones. Pharm Chem J 45, 536–538 (2011). https://doi.org/10.1007/s11094-011-0674-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-011-0674-z