Several analogs of the antihistamine drug dimebon have been synthesized with different linkers connecting a picoline fragment to the tetrahydropyridoindole core. Radioligand activity profiles of the obtained compounds have been studied using a broad set of 30 therapeutic targets. Reduction of the linker length is shown to cause substantial shifts in the activity profiles.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 9, pp. 12–17, September, 2011.
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Ivashchenko, A.V., Mit’kin, O.D., Okun’, I.M. et al. Syntheses and radioligand activities of dimebon analogs. Pharm Chem J 45, 526–531 (2011). https://doi.org/10.1007/s11094-011-0672-1
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DOI: https://doi.org/10.1007/s11094-011-0672-1