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Synthesis and cytotoxic activity of azidonaphthazarins

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Pharmaceutical Chemistry Journal Aims and scope

Preparative methods have been developed for the synthesis of azidonaphthazarins. It is established that 2-hydroxy- and 2-alkoxy-6,7-dichloronaphthazarins react regiospecifically with sodium azide in MeOH to yield the corresponding 6-azido derivatives. The cytotoxic activity and contraceptive properties of the synthesized azidonaphthazarins have been investigated using the sperm and eggs of the sea urchin Strongylocentrotus intermedius.

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Notes

  1. Structures of naphthazarin derivatives are given herein only for one of the possible tautomers if not otherwise specified.

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Acknowledgments

The work was financed partially by the Interdisciplinary Integrated Project of the Far-East, Siberian, and Urals Branches of the RAS (No. 09-II-SU-05-001) and the RAS Presidium Program “Molecular and Cellular Biology”.

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Authors and Affiliations

  1. Pacific Institute of Bioorganic Chemistry, Far-East Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia

    N. D. Pokhilo, M. I. Kiseleva & V. F. Anufriev

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  1. N. D. Pokhilo
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  2. M. I. Kiseleva
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  3. V. F. Anufriev
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Correspondence to N. D. Pokhilo.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 9, pp. 8–11, September, 2011.

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Pokhilo, N.D., Kiseleva, M.I. & Anufriev, V.F. Synthesis and cytotoxic activity of azidonaphthazarins. Pharm Chem J 45, 522–525 (2011). https://doi.org/10.1007/s11094-011-0671-2

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