Desmopressin is used for preventing and stopping hemorrhage of various etiologies and is included in the list of most essential drugs. Quantative determination of desmopressin in blood plasma using gas chromatography—mass spectrometry (HPLC/MS) is discussed. A method for the isolation of desmopressin from plasma samples and quantitative determination of desmopressin is described. The percent extraction of the drug from blood plasma has been estimated and the influence of the biological matrix has been assessed. The work has been carried out using a Thermo Finnigan HPLC/MS instrument equipped with an external ion-source based on electrospray ionization.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 8, pp. 53 – 55, August, 2011.
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Nguyen, C.T., Karlitskaya, A.A., Davydova, K.S. et al. Determination of desmopressin by HPLC–MS. Pharm Chem J 45, 509–511 (2011). https://doi.org/10.1007/s11094-011-0666-z
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DOI: https://doi.org/10.1007/s11094-011-0666-z