Reaction of acetoacetic esters, aromatic aldehydes, and ammonia formed under Hantzsch conditions 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines. The structures of the products were established using mass, IR, and PMR spectra. It was found that all synthesized compounds exhibited moderate antimicrobial activity.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 8, pp. 28 – 29, August, 2011.
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Gein, V.L., Kazantseva, M.I., Kurbatova, A.A. et al. Synthesis and antimicrobial activity of 2,6-dimethyl-3,5-dialkoxycarbonyl-4-phenyl- 1,4-dihydropyridines. Pharm Chem J 45, 474–475 (2011). https://doi.org/10.1007/s11094-011-0659-y
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DOI: https://doi.org/10.1007/s11094-011-0659-y