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Effects of melatonin on the activity of the glutathione antioxidant system and various NADPH-generating enzymes in the liver and blood of rats with type 2 diabetes mellitus

The actions of melatonin on the activity of the glutathione antioxidant system and various NADPH-generating enzymes in rats with type 2 diabetes mellitus were studied. The development of this pathology was found to be accompanied by increases in the activities of glutathione reductase (E.C. 1.6.4.2), glutathione peroxidase (E.C. 1.11.1.9), and NADP-isocitrate dehydrogenase (NADP-IDH, E.C. 1.1.1.41), along with decreases in the activity of glucose-6-phosphate dehydrogenase (G6PDH, E.C. 1.1.1.49) in both the liver and serum as compared with animals without pathology. In addition, there was a decrease in the level of reduced glutathione. Administration of melatonin induced changes in the study parameters towards control values. This effect appeared to be linked to decreases in the loading on the glutathione antioxidant system due to the antioxidant properties of this hormone, which are associated with the features of its chemical structure which allow it to interact efficiently with free radicals to form metabolites with little or no toxicity.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 7, pp. 7 – 10, July, 2011.

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Agarkov, A.A., Popova, T.N. & Matasova, L.V. Effects of melatonin on the activity of the glutathione antioxidant system and various NADPH-generating enzymes in the liver and blood of rats with type 2 diabetes mellitus. Pharm Chem J 45, 385–388 (2011). https://doi.org/10.1007/s11094-011-0640-9

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  • DOI: https://doi.org/10.1007/s11094-011-0640-9

Key words

  • Melatonin
  • type 2 diabetes mellitus in rats
  • glutathione antioxidant system