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Interpolymer combinations of chemically complementary grades of Eudragit copolymers: a new direction in the design of peroral solid dosage forms of drug delivery systems with controlled release (review)

  • Drug Synthesis Methods and Manufacturing Technology
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Pharmaceutical Chemistry Journal Aims and scope

Principles of the combination of chemically complementary grades of Eudragit® copolymers in peroral, matrix, and reservoir types of solid dosage forms with modified release [tablets, microspheres, (micro)pellets] and their manufacturing technology (including film coatings) are considered. Modified drug release is achieved due to the interaction between reactive groups of copolymer pairs, which controls the drug release process both inside matrices and within multilayers or combined coatings. Analysis of these processes has key significance for developing (meth)acrylate polycomplexes, which could be synthesized in both aqueous and organic media, as new classes of drug carriers for constructing modern peroral drug delivery systems.

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Acknowledgments

We thank Dr. Chem. Sci. V. A. Kemenova for discussion of certain key aspects of the work and graduate and undergraduate students of the Department of Pharmaceutical Chemistry from courses in analytical and toxicological chemistry of KSMU who participated in carrying out several of the studies cited above.

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  1. Kazan State Medical University, Kazan, Tatarstan, 420008, Russia

    R. I. Mustafin

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Correspondence to R. I. Mustafin.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 5, pp. 28 – 39, May, 2011.

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Mustafin, R.I. Interpolymer combinations of chemically complementary grades of Eudragit copolymers: a new direction in the design of peroral solid dosage forms of drug delivery systems with controlled release (review). Pharm Chem J 45, 285–295 (2011). https://doi.org/10.1007/s11094-011-0618-7

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  • DOI: https://doi.org/10.1007/s11094-011-0618-7

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