The reaction of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid N-heterylamides with dichlorides of manganese, cobalt, and nickel forms the bis[3-aryl-1-(N-heteryl)carboxamido-1, 3-propanedionato] complexes of manganese, cobalt, and nickel, respectively. The hypoglycemic and anti-inflammatory activities of the synthesized compounds and the previously obtained complexes of copper, zinc, and cadmium were investigated. Several highly active substances with two pharmacological effects were found among these products.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
P. Dandona, A. Aljada, and A. Bandyopadhyay, Trends Immunol., 25(1), 4 – 7 (2004).
V. Shvarts, Ter. Arkh., 10, 74 – 80 (2009).
H. Tilg and A. R. Moschen, Mol. Med. (Manhasset, NY, United States), 14(3 – 4), 222 – 231 (2008).
M. Sonmez, I. Berberb, and E. Akbas, Eur. J. Med. Chem., 41(1), 111 – 115 (2006).
A. Bacchi, M. Biemmi, M. Carcelli, et al., J. Med. Chem., 51(22), 7253 – 7264 (2008).
N. A. Pulina, V. V. Zalesov, and P. A. Mokin, Bashk. Khim. Zh., 14(3), 52 – 56 (2007).
N. A. Pulina, P. A. Mokin, V. V. Yushkov, et al., Khim.-farm. Zh., 42(7), 14 – 16 (2008).
R. U. Khabriev (ed.), Handbook of Experimental (Preclinical) Study of New Drugs [in Russian], Meditsina, Moscow (2005).
I. A. Volchegorskii, L. M. Rassokhina, and I. Yu. Miroshnichenko, Probl. Endokrinol., 54(5), 43 – 50 (2008).
Methodical Recommendations for Experimental Study of Non-steroidal Anti-inflammatory Agents [in Russian], Pharmacological Committee, MZ, USSR, Protocol No. 22, Nov. 11, 1982, Moscow (1982).
Acknowledgments
The work was supported financially by the Russian Foundation for Basic Research (Project No. 08-03-00488a).
Author information
Authors and Affiliations
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 45, No. 5, pp. 18 – 21, May, 2011.
Rights and permissions
About this article
Cite this article
Pulina, N.A., Sobin, F.V., Krasnova, A.I. et al. Synthesis and hypoglycemic and anti-inflammatory activity of metal complexes of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid N-heterylamides. Pharm Chem J 45, 275–278 (2011). https://doi.org/10.1007/s11094-011-0615-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-011-0615-x